Document Detail

Osteoporotic fractures at presentation of Cushing's disease: two case reports and a literature review.
MedLine Citation:
PMID:  10963086     Owner:  NLM     Status:  MEDLINE    
Osteoporosis is a common complication of Cushing's disease/syndrome. Fractures can be the presenting manifestation. We report two cases and review 28 others from the literature. Clinical, laboratory, and absorptiometry data are reviewed; the vertebrae and ribs were the most common fracture sites, and osteoporosis reversal after treatment varied with age, gender, and symptom duration. The pathophysiology, which remains controversial, is discussed. A search for Cushing's disease/syndrome should be part of the routine evaluation of osteoporosis in children and adults, particularly men.
V Khanine; J J Fournier; E Requeda; J P Luton; F Simon; J Crouzet
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Joint, bone, spine : revue du rhumatisme     Volume:  67     ISSN:  1297-319X     ISO Abbreviation:  Joint Bone Spine     Publication Date:  2000  
Date Detail:
Created Date:  2000-12-04     Completed Date:  2000-12-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100938016     Medline TA:  Joint Bone Spine     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  341-5     Citation Subset:  IM    
Rheumatology Department, Sud-Francilien Hospital Center, Corbeil-Essonnes, France.
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MeSH Terms
Absorptiometry, Photon
Alendronate / therapeutic use
Bone and Bones / pathology,  radiography
Cushing Syndrome / complications*,  pathology,  radiography
Fractures, Spontaneous / etiology*,  pathology,  radiography
Osteoporosis / drug therapy,  etiology*,  pathology,  radiography
Treatment Outcome
Reg. No./Substance:

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