Document Detail

Osteoporosis treatment and progression of aortic stenosis.
MedLine Citation:
PMID:  19576331     Owner:  NLM     Status:  MEDLINE    
A decrease in bone mineral density has been reported to be associated with increased progression of aortic stenosis (AS). We hypothesized that osteoporosis treatment (OT) is associated with decreased progression of AS. We performed an observational study of patients with AS from our echocardiographic database comparing 18 patients on OT (bisphosphonates, calcitonin, or estrogen receptor modulators) with 37 patients not on OT. All patients had serial echocardiograms. Patients with mitral stenosis, aortic valve replacement, renal failure, calcium disorders, or left ventricular ejection fraction <40% were excluded. Aortic valve area (AVA) was calculated using the continuity equation. There was no significant difference in age, gender, renal function, hypertension, statin use, diabetes, or calcium level between the 2 groups. Mean baseline AVA was 1.33 cm(2) and not significantly different between groups. After a mean of 2.4 +/- 1.0 years, mean annual changes in AVA were -0.22 +/- 0.22 cm(2) in those not on OT and -0.10 +/- 0.18 cm(2) in patients receiving OT (p = 0.025). There was a graded association between AS progression rate and OT. In a multivariable analysis including age, gender, and statin use, only OT was associated with a change in AVA. In conclusion, OT is strongly and independently associated with decreased progression of AS. This association warrants investigation in a larger, prospective study.
Adam H Skolnick; Martin Osranek; Philip Formica; Itzhak Kronzon
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-05-04
Journal Detail:
Title:  The American journal of cardiology     Volume:  104     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-06     Completed Date:  2009-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  122-4     Citation Subset:  AIM; IM    
New York University Medical Center, New York, NY, USA.
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MeSH Terms
Aged, 80 and over
Aortic Valve
Aortic Valve Stenosis / etiology,  physiopathology*,  prevention & control,  ultrasonography
Bone Density / drug effects
Bone Density Conservation Agents / therapeutic use
Disease Progression
Multivariate Analysis
Osteoporosis / complications,  drug therapy,  physiopathology*,  ultrasonography
Regression Analysis
Retrospective Studies
Ventricular Function, Left
Reg. No./Substance:
0/Bone Density Conservation Agents
Comment In:
Am J Cardiol. 2009 Jul 1;104(1):125-7   [PMID:  19576332 ]

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