Document Detail


Osteoporosis and transforming growth factor-beta-1 gene polymorphism in Chinese men and women.
MedLine Citation:
PMID:  14999526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transforming growth factor-beta-1 (TGF-Beta(1)) has been implicated in bone mineral density (BMD) determination. We investigated the relationship between the TGF polymorphism, BMD, and vertebral fractures in 588 Chinese men and women. No association between TGF polymorphism and BMD was observed in postmenopausal women (aged 55-59 years), elderly men (aged 70-79 years), or elderly women (aged 70-79 years) at the hip, spine, or total body ( P >> 0.05 by two-way ANOVA). In all study groups, there was no effect of an interaction between TGF polymorphism and calcium intake on BMD ( P >> 0.05 for the interaction effects by two-way ANOVA). No statistical significant association was observed between TGF polymorphism and vertebral fracture in elderly men or women ( P >> 0.05 by the chi-square test), even though men of the TT and TC genotypes seem to have more vertebral fractures. Contrary to previous studies that found an association between BMD and TGF polymorphism in the Japanese, we found no association between TGF polymorphism and BMD of elderly Chinese men or women. This finding could result from different sampling methods between the previous and current studies and environmental factors and ethnic differences between the two populations.
Authors:
Edith Ming Chu Lau; Samuel Yeung Shan Wong; Martin Li; Chun Hung Ma; Pak Leong Lim; Jean Woo
Related Documents :
2626976 - Preventive effects of transdermal administration of 17 beta-estradiol on postmenopausal...
6652546 - Does postmenopausal bone loss respond to estrogen replacement therapy independent of bo...
16767526 - Teriparatide's effects on quantitative ultrasound parameters and bone density in women ...
10234586 - Determinants of peak bone mass: clinical and genetic analyses in a young female canadia...
24626266 - Morbidity, mortality, and categorization of the risk of perioperative complications in ...
15748796 - Smoke composition and predicting relationships for international commercial cigarettes ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of bone and mineral metabolism     Volume:  22     ISSN:  0914-8779     ISO Abbreviation:  J. Bone Miner. Metab.     Publication Date:  2004  
Date Detail:
Created Date:  2004-03-04     Completed Date:  2004-10-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9436705     Medline TA:  J Bone Miner Metab     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  148-52     Citation Subset:  IM    
Affiliation:
Department of Family and Community Medicine, Chinese University of Hong Kong, Hong Kong. edithlau@cuhk.edu.hk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Bone Density*
Calcium, Dietary
China
Female
Genotype
Hip / radiography
Humans
Male
Middle Aged
Osteoporosis / genetics*,  metabolism
Polymorphism, Genetic*
Spinal Fractures
Spine / radiography
Statistics as Topic
Transforming Growth Factor beta / genetics*
Transforming Growth Factor beta1
Chemical
Reg. No./Substance:
0/Calcium, Dietary; 0/TGFB1 protein, human; 0/Transforming Growth Factor beta; 0/Transforming Growth Factor beta1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of vitamin D receptor and estrogen receptor gene polymorphism on the relationship between die...
Next Document:  Less invasive surgery for primary hyperparathyroidism based on preoperative 99mTc-hexakis-2-methoxyi...