Document Detail

Osteoporosis in beta-thalassemia: Clinical and genetic aspects.
MedLine Citation:
PMID:  16339696     Owner:  NLM     Status:  MEDLINE    
Osteoporosis and osteopenia are frequent complications of thalassemia major (TM) and intermedia (TI). Osteoporosis was found in 23/25 patients with TI and in 115/239 patients with TM. In TM, no association was found with specific polymorphisms in candidate genes (vitamin D receptor, estrogen receptor, calcitonin receptor, and collagen type 1 alpha 1). Osteoporosis in female patients with TM was strongly associated with primary amenorrhea (P < .0001), while in male patients with TM, hypogonadism was not significantly related to bone mineral density (BMD) (P = .0001). Low BMD was also associated with cardiomiopathy (P = .01), diabetes mellitus (P = .0001), chronic hepatitis (P = .0029), and increased ALT (P = .01).
R Origa; E Fiumana; M R Gamberini; S Armari; M Mottes; A Sangalli; E Paglietti; R Galanello; C Borgna-Pignatti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1054     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  451-6     Citation Subset:  IM    
Ospedale Microcitemico, University of Cagliari, Via jenner, 09121 Cagliari, Italy.
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MeSH Terms
Amenorrhea / etiology
Bone Density
Bone Diseases, Metabolic / etiology,  genetics
Cardiomyopathies / etiology
Collagen Type I / genetics
DNA Mutational Analysis
Diabetes Mellitus / etiology
Estrogen Receptor alpha / genetics
Genetic Predisposition to Disease
Hypogonadism / etiology
Hypothyroidism / etiology
Osteoporosis / etiology*,  genetics
Receptors, Calcitonin / genetics
Receptors, Calcitriol / genetics
beta-Thalassemia / complications*,  genetics
Reg. No./Substance:
0/Collagen Type I; 0/Estrogen Receptor alpha; 0/Receptors, Calcitonin; 0/Receptors, Calcitriol

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