| Osteoporosis in beta-thalassemia: Clinical and genetic aspects. | |
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MedLine Citation:
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PMID: 16339696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Osteoporosis and osteopenia are frequent complications of thalassemia major (TM) and intermedia (TI). Osteoporosis was found in 23/25 patients with TI and in 115/239 patients with TM. In TM, no association was found with specific polymorphisms in candidate genes (vitamin D receptor, estrogen receptor, calcitonin receptor, and collagen type 1 alpha 1). Osteoporosis in female patients with TM was strongly associated with primary amenorrhea (P < .0001), while in male patients with TM, hypogonadism was not significantly related to bone mineral density (BMD) (P = .0001). Low BMD was also associated with cardiomiopathy (P = .01), diabetes mellitus (P = .0001), chronic hepatitis (P = .0029), and increased ALT (P = .01). |
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Authors:
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R Origa; E Fiumana; M R Gamberini; S Armari; M Mottes; A Sangalli; E Paglietti; R Galanello; C Borgna-Pignatti |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1054 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-12-12 Completed Date: 2006-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 451-6 Citation Subset: IM |
Affiliation:
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Ospedale Microcitemico, University of Cagliari, Via jenner, 09121 Cagliari, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amenorrhea / etiology Bone Density Bone Diseases, Metabolic / etiology, genetics Cardiomyopathies / etiology Collagen Type I / genetics DNA Mutational Analysis Diabetes Mellitus / etiology Estrogen Receptor alpha / genetics Female Genetic Predisposition to Disease Humans Hypogonadism / etiology Hypothyroidism / etiology Male Osteoporosis / etiology*, genetics Receptors, Calcitonin / genetics Receptors, Calcitriol / genetics beta-Thalassemia / complications*, genetics |
| Chemical | |
Reg. No./Substance:
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0/Collagen Type I; 0/Estrogen Receptor alpha; 0/Receptors, Calcitonin; 0/Receptors, Calcitriol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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