Document Detail


Osteoporosis in beta-thalassemia: Clinical and genetic aspects.
MedLine Citation:
PMID:  16339696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Osteoporosis and osteopenia are frequent complications of thalassemia major (TM) and intermedia (TI). Osteoporosis was found in 23/25 patients with TI and in 115/239 patients with TM. In TM, no association was found with specific polymorphisms in candidate genes (vitamin D receptor, estrogen receptor, calcitonin receptor, and collagen type 1 alpha 1). Osteoporosis in female patients with TM was strongly associated with primary amenorrhea (P < .0001), while in male patients with TM, hypogonadism was not significantly related to bone mineral density (BMD) (P = .0001). Low BMD was also associated with cardiomiopathy (P = .01), diabetes mellitus (P = .0001), chronic hepatitis (P = .0029), and increased ALT (P = .01).
Authors:
R Origa; E Fiumana; M R Gamberini; S Armari; M Mottes; A Sangalli; E Paglietti; R Galanello; C Borgna-Pignatti
Related Documents :
3436356 - Adaptation of estrogen-dependent mcf-7 cells to low estrogen (phenol red-free) culture.
11696396 - Er-dependent estrogenic activity of parabens assessed by proliferation of human breast ...
12605406 - Estrogen receptor-alpha is required for estrogen-induced mu-opioid receptor internaliza...
3840166 - Modulation of the estrogen receptor's affinity for dna by estradiol.
6306616 - Activation of angiotensin ii receptors in brain potentiates the stimulating effect of e...
25446766 - Role of intra-hippocampal orexin 1 and orexin 2 receptors in conditioned place preferen...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1054     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  451-6     Citation Subset:  IM    
Affiliation:
Ospedale Microcitemico, University of Cagliari, Via jenner, 09121 Cagliari, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Amenorrhea / etiology
Bone Density
Bone Diseases, Metabolic / etiology,  genetics
Cardiomyopathies / etiology
Collagen Type I / genetics
DNA Mutational Analysis
Diabetes Mellitus / etiology
Estrogen Receptor alpha / genetics
Female
Genetic Predisposition to Disease
Humans
Hypogonadism / etiology
Hypothyroidism / etiology
Male
Osteoporosis / etiology*,  genetics
Receptors, Calcitonin / genetics
Receptors, Calcitriol / genetics
beta-Thalassemia / complications*,  genetics
Chemical
Reg. No./Substance:
0/Collagen Type I; 0/Estrogen Receptor alpha; 0/Receptors, Calcitonin; 0/Receptors, Calcitriol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Longitudinal study of survival and causes of death in patients with thalassemia major in Greece.
Next Document:  Quality of life in patients with thalassemia intermedia compared to thalassemia major.