| Osteoporosis in HFE2 juvenile hemochromatosis. A case report and review of the literature. | |
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MedLine Citation:
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PMID: 15997423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Juvenile hemochromatosis (JH) is a severe form of hemochromatosis, which involves rapid iron overload and leads to organ damage, typically before the age of 30. We report a single case of a 25-year-old man suffering from juvenile hemochromatosis, with aggressive clinical manifestations, typically characterized by transaminasemia and progressive erectile dysfunction, due to hypogonadotropic hypogonadism. The clinical case appears interesting, as the patient also had secondary osteoporosis accompanied by increased bone resorption, which prevalently affected trabecular bone. Approximately 6 months after normalization of serum ferritin levels was achieved by frequent phlebotomies, he became eugonadal and bone mineral density of the lumbar spine increased. Our observations suggest that osteoporosis might occur in the state of JH even at a young age, mainly due to the deprivation of sex steroids and the direct tissue toxicity of iron. |
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Authors:
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Nicholas G Angelopoulos; Anastasia K Goula; George Papanikolaou; George Tolis |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2005-07-05 |
Journal Detail:
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Title: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Volume: 17 ISSN: 0937-941X ISO Abbreviation: Osteoporos Int Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-19 Completed Date: 2006-07-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100105 Medline TA: Osteoporos Int Country: England |
Other Details:
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Languages: eng Pagination: 150-5 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Metabolism, Hippokrateion Hospital of Athens, Vassilisis Sofias Avenue 108, 115 27, Athens, Greece. drangelnick@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bone Density Bone and Bones / metabolism Hemochromatosis / complications*, genetics, physiopathology Humans Hypogonadism / complications Male Membrane Proteins / genetics* Mutation Osteoporosis / etiology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/HFE2 protein, human; 0/Membrane Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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