Document Detail

Osteoporosis associated with the treatment of paraphilias: a clinical review of seven case reports.
MedLine Citation:
PMID:  12877306     Owner:  NLM     Status:  MEDLINE    
Osteoporosis and long-term androgen suppression in the treatment of paraphilias has been documented with surgical castration and the use of gonadotropin-releasing hormone agonists. The literature has suggested that the use of cyproterone acetate (CPA) may be protective against osteoporosis, although there are case reports of osteoporosis in men treated with CPA. This pilot study represents a case series of seven patients diagnosed with severe paraphilias and treated with CPA, leuprolide, or surgical castration. Two of the four patients treated with CPA developed significant osteoporosis, while the other two had normal bone density studies. The remaining three patients, one treated with leuprolide and two with surgical castration, had osteopenia. Based upon the current literature, the finding of significant osteoporosis in two of four patients treated with CPA, but not those treated with leuprolide or castration, is surprising. Monitoring of all patients treated with long-term androgen suppression for osteoporosis is suggested.
Linda J Grasswick; John M W Bradford
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of forensic sciences     Volume:  48     ISSN:  0022-1198     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-24     Completed Date:  2003-09-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  849-55     Citation Subset:  IM    
Youth Forensic Psychiatric Services, 5714 Glover Road, Langley, British Columbia, Canada.
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MeSH Terms
Androgen Antagonists / adverse effects*
Bone Density
Cyproterone Acetate / adverse effects*
Forensic Psychiatry
Leuprolide / therapeutic use
Middle Aged
Osteoporosis / chemically induced*
Paraphilias / drug therapy*
Pilot Projects
Reg. No./Substance:
0/Androgen Antagonists; 427-51-0/Cyproterone Acetate; 53714-56-0/Leuprolide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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