Document Detail

Osteoporosis is associated with the risk of colorectal adenoma in women.
MedLine Citation:
PMID:  23303144     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: : Recently, it was reported that postmenopausal women with lower bone mineral density have an increased risk of colorectal cancer. An association between lower bone mineral density and colorectal cancer suggests that colorectal adenoma, which is a precursor of colorectal cancer, may also be associated with lower bone mineral density.
OBJECTIVE: : The aim of this study was to determine the association between colorectal adenoma and osteoporosis.
DESIGN AND PATIENTS: : We conducted a retrospective cross-sectional study between January 2007 and May 2011. Women older than 50 years of age who underwent dual-energy x-ray absorptiometry for bone mineral density and screening colonoscopy at Gangdong Kyung Hee University Hospital in Korea during a routine health checkup were eligible for this study. We performed multivariate analysis adjusted for age, family history of colorectal cancer, alcohol consumption, current smoking, regular aspirin use, exercise, menopause, and postmenopausal hormone use to identify independent predictors for the presence of colorectal adenoma.
MAIN OUTCOME MEASURES: : The primary outcome measured was the prevalence of colorectal adenoma according to the bone mineral density level.
RESULTS: : A total of 992 women older than 50 years were assigned to an osteoporosis group (n = 231) or a control group (n = 231) after menopause matching. In univariate analysis, the proportion of colorectal adenoma was significantly higher in the osteoporosis group than in the control group (29.9% vs 20.8%, p = 0.025). Furthermore, osteoporosis (OR = 1.592, 95% CI = 1.004-2.524, p = 0.048) was found to be an independent risk factor for the presence of colorectal adenoma.
CONCLUSIONS: : Osteoporosis is associated with an increased risk of colorectal adenoma in women older than 50 years.
Jun Uk Lim; Jae Myung Cha; Joung Il Lee; Kwang Ro Joo; Hyun Phil Shin; Jae Jun Park; Jung Won Jeon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  56     ISSN:  1530-0358     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  169-74     Citation Subset:  IM    
1 Department of Internal Medicine, Gangdong Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Korea 2 Graduate School, Kyung Hee University, Seoul, Korea.
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