Document Detail

Osteoporosis as the presenting sign of leukemic relapse in an adolescent: case report and literature review.
MedLine Citation:
PMID:  1610848     Owner:  NLM     Status:  MEDLINE    
Osteoporosis in adolescence is rare and usually secondary to an underlying disease process whose diagnosis may be difficult to detect. Osteoporotic vertebral collapse is an uncommon presenting sign of acute lymphoblastic leukemia (ALL). We describe a 13-year-old boy with osteoporotic vertebral collapse secondary to relapse of ALL whose blood count and blood morphology were normal but whose 1,25 = (OH2) = vitamin D level was deficient. A combination of chemotherapy, calcitriol and calcitonin therapy was successful in reversing the process. His case is presented to describe the diagnostic and therapeutic issues involved.
R D Rohn; E J Werner; R L Byrd
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Journal of adolescent health : official publication of the Society for Adolescent Medicine     Volume:  13     ISSN:  1054-139X     ISO Abbreviation:  J Adolesc Health     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-29     Completed Date:  1992-07-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9102136     Medline TA:  J Adolesc Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  306-10     Citation Subset:  IM    
Department of Pediatrics, Eastern Virginia Medical School, Norfolk.
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MeSH Terms
Calcitonin / therapeutic use
Calcitriol / blood,  therapeutic use
Calcium / urine
Hydroxyproline / urine
Osteoporosis / diagnosis,  drug therapy,  etiology*,  metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*,  metabolism
Remission Induction
Reg. No./Substance:
32222-06-3/Calcitriol; 51-35-4/Hydroxyproline; 7440-70-2/Calcium; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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