Document Detail


Osteoporosis after cardiac transplantation.
MedLine Citation:
PMID:  8452149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The purpose of this study was to determine the prevalence of osteopenia and fractures and to describe the biochemical indices of mineral metabolism in patients who have undergone cardiac transplantation. PATIENTS AND METHODS: Forty adult patients who had received a cardiac transplant between 1982 and 1990 and who were receiving immunosuppressive therapy with prednisone and cyclosporine A were studied. Bone densitometric measurements by dual-energy x-ray absorptiometry of the lumbar spine and femoral neck and radiographs of the thoracic and lumbar spine were obtained for all patients. Routine serum and urine biochemical values as well as more specialized biochemical analyses (intact parathyroid hormone, metabolites of vitamin D, and osteocalcin) were obtained. RESULTS: Osteopenia was present in 28% of the patients at the lumbar spine and 20% of the patients at the femoral neck. Vertebral fractures were present in 35% of patients. In contrast to other patients receiving glucocorticoids, serum osteocalcin, a marker of bone formation, was elevated in 60% of patients. CONCLUSIONS: Osteopenia and vertebral fractures are common in patients after cardiac transplantation. The presence of elevated osteocalcin levels suggests that the pathogenesis of the osteoporosis in these patients differs from that of glucocorticoid-induced osteoporosis.
Authors:
E Shane; M C Rivas; S J Silverberg; T S Kim; R B Staron; J P Bilezikian
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  94     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-13     Completed Date:  1993-04-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  257-64     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Bone Density
Cyclosporine / therapeutic use
Female
Femur Neck / metabolism,  radiography
Heart Transplantation*
Humans
Lumbar Vertebrae / injuries*,  metabolism,  radiography
Male
Middle Aged
Osteoporosis / drug therapy,  epidemiology,  etiology*,  metabolism*,  radiography
Postoperative Complications / drug therapy,  epidemiology,  metabolism*,  radiography
Prednisone / therapeutic use
Prevalence
Spinal Fractures / epidemiology,  etiology*,  metabolism,  radiography
Grant Support
ID/Acronym/Agency:
RR 006645/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
53-03-2/Prednisone; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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