| Osteoporosis Screening Using Areal Bone Mineral Density Estimation from Diagnostic CT Images. | |
| | |
MedLine Citation:
|
PMID: 22958722 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
RATIONALE AND OBJECTIVES: A reliable and cost-effective method for osteoporosis screening is important in addressing the increase in osteoporotic fractures due to aging populations. Diagnostic computed tomographic (dCT) images may contain densitometric information useful for osteoporosis screening. The aim of this study was to investigate the relationship between areal bone mineral density (aBMD) and volumetric information on dCT imaging and its suitability for building an osteopenia screening system. The goal of this system is to estimate aBMD and predict bone disease condition on the basis of dCT images of the lumbar spine. MATERIALS AND METHODS: Dual-energy x-ray absorptiometry (DXA) aBMD and computed tomographic (CT) images were obtained from 44 male patients (mean age, 60 years). An aBMD from CT images (aBMD(CT)) was computed from the CT volume using established relationships of Hounsfield units to bone density and used to estimate DXA-derived aBMD (aBMD(DxA)). Estimated aBMD(CT) was then applied to diagnose osteopenia of the lumbar spine using statistical methods. RESULTS: For the estimation of aBMD(DxA) from aBMD(CT), the proposed approach yielded a high correlation factor of r = 0.852, with a root mean square error of 0.0884 g/cm(2). The correlation was strongest when every slice in the dCT volume and both trabecular and cortical bone components were used. The classifier achieved an overall classification accuracy of 80.1% and an area under the receiver-operating characteristic curve of 0.894. CONCLUSIONS: This clinical study demonstrates that aBMD(DxA) can be determined from routine CT data. Estimated aBMD(DxA) can be extended to form a dCT imaging-based opportunistic screening system for the detection and management of osteopenia. |
| | |
Authors:
|
Wei-Liang Tay; Chee-Kong Chui; Sim-Heng Ong; Alvin Choong-Meng Ng |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Academic radiology Volume: 19 ISSN: 1878-4046 ISO Abbreviation: Acad Radiol Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-09-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9440159 Medline TA: Acad Radiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1273-82 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 AUR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Electrical and Computer Engineering, National University of Singapore, Block E4, Level 8, Room 25, 4 Engineering Drive 3, Singapore 117583. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Retail Venue Based Screening Mammography: Assessment of Women's Preferences.
Next Document: Antibiotic resistance patterns and extended-spectrum ?-lactamase production among Acinetobacter spp....