Document Detail

Osteopontin is released from the heart into the coronary circulation in patients with a previous anterior wall myocardial infarction.
MedLine Citation:
PMID:  12939547     Owner:  NLM     Status:  MEDLINE    
The present study was designed to clarify whether osteopontin, an extracellular matrix protein, is released from the heart into the coronary circulation in patients with a previous (>3 months) anterior wall myocardial infarction (MI). Using a commercially available enzyme immunoassay kit, plasma concentrations of osteopontin were measured in 30 patients (26 men, 4 women; mean age, 61+/-12 years). Blood samples were obtained from the aortic root and coronary sinus. The difference in the plasma concentrations of osteopontin in the aortic root and coronary sinus, which reflects the cardiac production of osteopontin released into the coronary circulation, was compared with the left ventricular ejection fraction (LVEF) and volumes obtained from contrast left ventriculography. Plasma osteopontin concentrations were significantly higher in the coronary sinus than in the aortic root (672+/-446 vs 610+/-398 ng/ml, p=0.02). The transcardiac gradient of plasma osteopontin concentration correlated negatively with LVEF (r=-0.55, p=0.0005) and positively with left ventricular (LV) end-diastolic (r=0.63, p=0.0001) and end-systolic volume indexes (r=0.79, p<0.0001). This is the first study to show that in patients with a previous anterior wall MI osteopontin is released from the heart into the coronary circulation in proportion to the LV systolic function and volumes, suggesting that this extramatrix protein is associated with post-MI LV remodeling.
Akira Tamura; Maki Shingai; Nobuko Aso; Takayuki Hazuku; Masaru Nasu
Related Documents :
7511757 - Disparate inotropic and lusitropic responses to pimobendan in conscious dogs with tachy...
15878007 - Effect of transcatheter atrial septal defect closure in children on left ventricular di...
3901347 - Myocardial function in the critically ill: factors influencing left and right ventricul...
15096457 - Long-term inhibition of rho-kinase suppresses left ventricular remodeling after myocard...
19660597 - Relation between myocardial infarct size and ventricular tachyarrhythmia among patients...
21490327 - Effects of alcohol septal ablation on coronary microvascular function and myocardial en...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  67     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-26     Completed Date:  2004-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  742-4     Citation Subset:  IM    
Second Department of Internal Medicine, Oita Medical University, Oita, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Coronary Circulation*
Medical Records
Middle Aged
Myocardial Infarction / blood,  metabolism*,  physiopathology
Myocardium / metabolism*
Sialoglycoproteins / blood,  metabolism*
Stroke Volume
Time Factors
Ventricular Function, Left
Ventricular Remodeling
Reg. No./Substance:
0/SPP1 protein, human; 0/Sialoglycoproteins; 106441-73-0/Osteopontin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Investigation of the optimal treatment strategy for atrial fibrillation in Japan.
Next Document:  Supersensitive response to isoproterenol in patients with marked global reduction of cardiac metaiod...