Document Detail


Osteopontin: a new emerging role in psoriasis.
MedLine Citation:
PMID:  19301019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Osteopontin (OPN) is a phosphorylated acidic glycoprotein produced by cells of the immune system, epithelial tissue, smooth muscle cells, osteoblasts, and tumor cells. OPN interacts with integrins and CD44 to enhance Th1 and inhibit Th2 cytokine expression. The involvement of this molecule in the onset of psoriasis has not previously been studied. Here, we demonstrate that OPN is expressed in peripheral blood mononuclear cells and in skin biopsies of psoriatic patients. The study was conducted on 30 patients affected with plaque psoriasis, and on 11 healthy donors. Two blood samples and two skin samples from patients affected with atopic dermatitis were used as control for Th2 typical inflammatory skin disease. The analysis of IL-1beta, IFN-gamma, TauNuF-alpha, IL-8, and ICAM-1 showed the characteristic Th1 pattern in all the psoriatic blood and skin samples analyzed. This study offers an opportunity for understanding inflammation in psoriasis and supports the hypothesis that OPN could represent a potential target for therapeutic intervention in psoriatic patients.
Authors:
Elisabetta Buommino; Maria Antonietta Tufano; Nicola Balato; Nunzia Canozo; Maria Donnarumma; Lucia Gallo; Anna Balato; Fabio Ayala
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-20
Journal Detail:
Title:  Archives of dermatological research     Volume:  301     ISSN:  1432-069X     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-26     Completed Date:  2010-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  397-404     Citation Subset:  IM    
Affiliation:
Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, Second University of Naples, Naples, Italy.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD44 / immunology
Biopsy
Gene Expression Regulation / immunology
Humans
Inflammation
Intercellular Adhesion Molecule-1 / genetics,  immunology,  metabolism
Interferon-gamma / genetics,  immunology,  metabolism
Interleukin-1beta / genetics,  immunology,  metabolism
Interleukin-8 / genetics,  immunology,  metabolism
Leukocytes, Mononuclear / immunology,  metabolism*,  pathology
Osteopontin / genetics,  immunology,  metabolism*
Psoriasis / genetics,  immunology*,  pathology,  physiopathology
Skin / immunology,  metabolism*,  pathology
Th1 Cells / immunology*
Th2 Cells / immunology
Chemical
Reg. No./Substance:
0/Antigens, CD44; 0/Interleukin-1beta; 0/Interleukin-8; 106441-73-0/Osteopontin; 126547-89-5/Intercellular Adhesion Molecule-1; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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