Document Detail

Osteopontin levels are elevated in patients with eosinophilic pneumonia.
MedLine Citation:
PMID:  20796249     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Osteopontin is a key cytokine involved in pro-inflammatory T helper type 1 (Th1)-associated immune responses, which has recently been implicated in allergic diseases. We investigated the pathogenic role of osteopontin in eosinophilic pneumonia.
METHODS: The concentrations of osteopontin and Th1- or Th2-associated cytokines were measured in BAL fluid (BALF) from 41 patients with eosinophilic pneumonia, including those with acute (AEP, n = 12), chronic (CEP, n = 16), or drug-induced eosinophilic pneumonia (DEP, n = 13). The results were compared with those from patients with other interstitial lung diseases. Immunocytochemistry and double immunofluorescence labelling were performed to determine the cellular source of osteopontin.
RESULTS: Osteopontin was significantly elevated in BALF from patients with eosinophilic pneumonia as compared with BALF from patients with drug-induced interstitial pneumonia, hypersensitivity pneumonitis, idiopathic interstitial pneumonia, or sarcoidosis, and also compared with BALF from healthy volunteers. Osteopontin concentrations elevated at the time of exacerbation decreased during clinical improvement, either spontaneously or as a result of corticosteroid therapy. Elevated concentrations of CXCL10, CCL17 and IL-10 were also detected in BALF from patients with eosinophilic pneumonia. Osteopontin concentrations in BALF of AEP patients were correlated with IL-5, as well as IL-10, CCL11, CCL17 and CXCL10 concentrations. In AEP and DEP patients, serum osteopontin concentrations were also elevated. Double immunofluorescence labelling showed that in patients with eosinophilic pneumonia, osteopontin was expressed in lung eosinophils.
CONCLUSIONS: Osteopontin is likely to contribute to the development of inflammation in patients with eosinophilic pneumonia.
Takuya Ueno; Eishi Miyazaki; Masaru Ando; Shin-ichi Nureki; Toshihide Kumamoto
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Publication Detail:
Type:  Journal Article     Date:  2010-08-27
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  15     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-29     Completed Date:  2011-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1111-21     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Respirology © 2010 Asian Pacific Society of Respirology.
Department of Internal Medicine 3, Faculty of Medicine, Oita University, Yufu, Oita, Japan.
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MeSH Terms
Acute Disease
Adrenal Cortex Hormones / therapeutic use
Aged, 80 and over
Alveolitis, Extrinsic Allergic / immunology
Bronchoalveolar Lavage Fluid / immunology*
Chronic Disease
Cytokines / analysis,  immunology
Lung Diseases, Interstitial / immunology
Middle Aged
Osteopontin / blood,  immunology*
Pulmonary Eosinophilia / drug therapy,  immunology*,  pathology
Retrospective Studies
Sarcoidosis / immunology,  pathology
Smoking / adverse effects
Young Adult
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Cytokines; 106441-73-0/Osteopontin

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