Document Detail

Osteopontin is associated with increased arterial stiffness in rheumatoid arthritis.
MedLine Citation:
PMID:  19603104     Owner:  NLM     Status:  MEDLINE    
Rheumatoid arthritis (RA) patients are characterized by increased arterial stiffness, an independent predictor of cardiovascular risk. It has been suggested that osteopontin (OPN), a cytokine involved in RA pathogenesis, might have vascular effects. To study a possible relationship between OPN and arterial stiffness, aortic pulse wave velocity (PWV) was measured by tonometry in 69 patients (41 with RA, 28 with systemic sclerosis [SSc]) and 18 healthy controls. Plasma OPN levels, oxidative stress markers, and endothelin 1 (ET-1) were assessed. OPN levels were significantly (P < 0.05) higher in RA (median 9.93, range 4.36-47.80 ng/mL) than in SSc (4.3, 2.1-19.7 ng/mL) or controls (5.2, 4.1-9.4 ng/mL). In RA patients, log-OPN was related to log-C-reactive protein (log-CRP) (r = 0.30, P < 0.05), age (r = 0.38, P < 0.01), Health Assessment Questionnaire (HAQ) (r = 0.58, P < 0.0001), and inversely related to total cholesterol (r = -0.33, P < 0.05) and apolipoprotein A (apoA) (r = -0.58, P < 0.001), but not to oxidative stress markers and ET-1. PWV was similar in RA (median 8.1, range 4.7-16.4 m/s) and SSc (median 8.7, range 7.1-13.1 m/s), but significantly greater (P < 0.01) than controls (median 7.5, range 4.1-10.4 m/s). Aortic PWV was related to log-OPN (r = 0.40, P < 0.01) only in RA patients. It also was related to age (r = 0.34, P < 0.05), mean blood pressure (r = 0.44, P < 0.001), and HAQ (r = 0.48, P < 0.001). In multiple regression analysis (r(2) = 0.36), including confounders, log-OPN remained a significant predictor (P < 0.05) of PWV in RA. Elevated plasma OPN levels are associated with increased arterial stiffness in RA patients, suggesting that this protein might represent a bridge protein between inflammation and the consequent joint damage and cardiovascular risk in RA patients.
Laura Bazzichi; Lorenzo Ghiadoni; Alessandra Rossi; Melania Bernardini; Mario Lanza; Francesca De Feo; Camillo Giacomelli; Ilaria Mencaroni; Katia Raimo; Marco Rossi; Anna Maria Mazzone; Stefano Taddei; Stefano Bombardieri
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Publication Detail:
Type:  Journal Article     Date:  2009-06-18
Journal Detail:
Title:  Molecular medicine (Cambridge, Mass.)     Volume:  15     ISSN:  1528-3658     ISO Abbreviation:  Mol. Med.     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-11-13     Completed Date:  2010-03-01     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  9501023     Medline TA:  Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  402-6     Citation Subset:  IM    
Department of Internal Medicine, Division of Rheumatology, University of Pisa, Pisa, Italy.
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MeSH Terms
Aorta / physiopathology*
Arteries / physiopathology
Arthritis, Rheumatoid / metabolism*,  physiopathology
Atherosclerosis / metabolism,  physiopathology*
Blood Flow Velocity
Blood Pressure
Case-Control Studies
Middle Aged
Osteopontin / blood*
Regression Analysis
Statistics, Nonparametric
Reg. No./Substance:

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