Document Detail

Osteopontin is Increased in the Cerebrospinal Fluid of Patients with Alzheimer's Disease and Its Levels Correlate with Cognitive Decline.
MedLine Citation:
PMID:  20009224     Owner:  NLM     Status:  Publisher    
Inflammation is believed to play a role in Alzheimer's disease (AD). Osteopontin (OPN) is a molecule involved in macrophage recruitment and activation and implicated in neurodegeneration. In order to elucidate the role of OPN in AD, we evaluated its levels in serum and cerebrospinal fluid (CSF) of 67 AD patients, 46 frontotemporal dementia (FTD) patients, and 69 controls. We found that OPN levels: i) are significantly increased in the CSF of AD patients; ii) correlate with MMSE score; and iii) are higher in the early disease phases ( 2 years). These findings support a role of OPN in AD pathogenesis.
Cristoforo Comi; Miryam Carecchio; Annalisa Chiocchetti; Stefania Nicola; Daniela Galimberti; Chiara Fenoglio; Giuseppe Cappellano; Francesco Monaco; Elio Scarpini; Umberto Dianzani
Related Documents :
3408614 - Computed tomography in patients with dementia probably due to toxic encephalopathy.
11419574 - Caregivers' judgments of the functional abilities of the alzheimer's disease patient: i...
3494754 - Differential diagnosis in dementia using the cerebral blood flow agent 99mtc hm-pao: a ...
9631454 - Mannan-binding lectin in human serum, cerebrospinal fluid and brain tissue and its role...
18478244 - Positive findings on mri in patients with asymmetrical snhl.
634 - Fasting uric acid and phosphate in urine and plasma of renal calcium-stone formers.
Publication Detail:
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  -     ISSN:  1875-8908     ISO Abbreviation:  -     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), "A. Avogadro" University of Eastern Piedmont, Novara, Italy Department of Neurology, "A. Avogadro" University of Eastern Piedmont, Maggiore Hospital, Novara, Italy Neurorehabilitation Institute "M.L. Novarese", Moncrivello (VC), Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reduced Homocysteine-Thiolactonase Activity in Alzheimer's Disease.
Next Document:  The Heme Degradation Pathway is a Promising Serum Biomarker Source for the Early Detection of Alzhei...