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Osteopontin is Increased in the Cerebrospinal Fluid of Patients with Alzheimer's Disease and Its Levels Correlate with Cognitive Decline.
MedLine Citation:
PMID:  20009224     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Inflammation is believed to play a role in Alzheimer's disease (AD). Osteopontin (OPN) is a molecule involved in macrophage recruitment and activation and implicated in neurodegeneration. In order to elucidate the role of OPN in AD, we evaluated its levels in serum and cerebrospinal fluid (CSF) of 67 AD patients, 46 frontotemporal dementia (FTD) patients, and 69 controls. We found that OPN levels: i) are significantly increased in the CSF of AD patients; ii) correlate with MMSE score; and iii) are higher in the early disease phases ( 2 years). These findings support a role of OPN in AD pathogenesis.
Authors:
Cristoforo Comi; Miryam Carecchio; Annalisa Chiocchetti; Stefania Nicola; Daniela Galimberti; Chiara Fenoglio; Giuseppe Cappellano; Francesco Monaco; Elio Scarpini; Umberto Dianzani
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  -     ISSN:  1875-8908     ISO Abbreviation:  -     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), "A. Avogadro" University of Eastern Piedmont, Novara, Italy Department of Neurology, "A. Avogadro" University of Eastern Piedmont, Maggiore Hospital, Novara, Italy Neurorehabilitation Institute "M.L. Novarese", Moncrivello (VC), Italy.
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