| Osteopontin Is an Activator of Human Adipose Tissue Macrophages and Directly Affects Adipocyte Function. | |
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MedLine Citation:
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PMID: 21467192 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Osteopontin (OPN) is highly up-regulated in adipose tissue in human and murine obesity and has been recently shown to be functionally involved in the pathogenesis of obesity-induced adipose tissue inflammation and associated insulin resistance in mice. OPN is a protein with multiple functions and acts as a chemokine and an inflammatory cytokine through a variety of different receptors (CD44, integrins). It is expressed in many cell types including adipose tissue macrophages (ATM). However, the target cells of OPN action in obese adipose tissue are still elusive. Here, we investigated expression of OPN receptors and the impact of OPN on ATM, adipocytes, and other cells of human adipose tissue. We found broad expression of OPN receptors in different adipose tissue cell types including adipocytes. OPN stimulated inflammatory signaling pathways and secretion of cytokines in model macrophages as well as isolated human ATM. Moreover, OPN impaired differentiation and insulin sensitivity of primary adipocytes as determined by peroxisomal proliferator-activated receptor-γ and adiponectin gene expression and insulin-stimulated glucose uptake. Furthermore, OPN induced inflammatory signaling in human adipocytes. In conclusion, OPN activates ATM and interferes with adipocyte function. Thus these data underline the potential of OPN as a therapeutic target for obesity-induced complications. |
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Authors:
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Maximilian Zeyda; Karina Gollinger; Jelena Todoric; Florian W Kiefer; Maike Keck; Oskar Aszmann; Gerhard Prager; Gerhard J Zlabinger; Peter Petzelbauer; Thomas M Stulnig |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-5 |
Journal Detail:
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Title: Endocrinology Volume: - ISSN: 1945-7170 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Clinical Division of Endocrinology and Metabolism (M.Z., K.G., J.T., F.W.K., T.M.S.), Department of Medicine III; Department of Surgery (M.K., O.A., G.P.); Institute of Immunology (G.J.Z.); and Department of Dermatology (P.P.), Medical University of Vienna, A-1090 Vienna, Austria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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