Document Detail

Osteopenia and osteoporosis can be predicted from Pap test.
MedLine Citation:
PMID:  18323270     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine sensitivity and specificity of Pap tests for osteopenia and osteoporosis using bone mineral density (BMD) with dual x-ray absorptiometry (DXA) as the reference standard. STUDY DESIGN: DXA measurement was performed on 136 routine Pap smears. Results of DXA measurement were expressed in T-scores, indicating degree of deviation compared to a young adult population of same age and gender. Smears were grouped into atrophic and mature cell patterns. Using a stereologic analysis, mean areas of squamous cells, their nuclei and their cytoplasm were estimated. RESULTS: There was significant positive correlation between cell area and T-score (p < 0.001), as well as between cytoplasm area and T-score (p < 0.001). There was no significant relationship between nucleus area and T-score (p > 0.05). Mean T-scores of patients with atrophic cells were significantly lower than mean T-scores of patients with mature cell patterns (p < 0.001). The group including patients with atrophic or mature cells had a sensitivity of 61.4% and specificity of 86.4%, with positive predictive value of 95.9% in detecting patients with osteopenia or osteoporosis. CONCLUSION: Women with atrophic smear pattern are susceptible to osteopenia or osteoporosis; many cases could be detected with routine Pap test without additional costs.
Alenka Repse-Fokter; Samo K Fokter
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  52     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-03-07     Completed Date:  2008-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-13     Citation Subset:  IM    
Department of Pathomorphology and Cytology, Celje General Hospital, Celje, Slovenia.
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MeSH Terms
Absorptiometry, Photon / methods
Bone Density
Bone Diseases, Metabolic / diagnosis*
Middle Aged
Osteoporosis / diagnosis
Vaginal Smears / methods

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