Document Detail

Osteonecrosis of the jaws associated with the use of yearly zoledronic acid: Report of 2 cases.
MedLine Citation:
PMID:  21523843     Owner:  NLM     Status:  Publisher    
BACKGROUND: Once-yearly zoledronic acid has been proven effective in the management of osteoporosis. Osteonecrosis of the jaws (ONJ) related to its use has not been reported since its approval in 2007. METHODS: Two women with osteoporosis/osteopenia developed ONJ after the second infusion of yearly zoledronic acid. They had no other systemic diseases and ONJ occurred after oral surgeries, which were performed about 2 months following drug administration. RESULTS: In 1 case osteonecrosis of the maxilla resolved after conservative therapy and sequestrectomy. In the other case bone necrosis developed on both sides of mandible, and the symptoms/signs of ONJ were partially responsive to conservative treatment. CONCLUSIONS: ONJ related to yearly zoledronic acid is a severe complication that should not be ignored. To minimize the risk, we recommend preventive oral care before the start of therapy and avoiding dental invasive procedures within 3 months after drug administration. © 2011 Wiley Periodicals, Inc. Head Neck, 2011.
Jang-Jaer Lee; Shih-Jung Cheng; Yi-Ping Wang; Jiiang-Huei Jeng; Chun-Pin Chiang; Sang-Heng Kok
Related Documents :
20451173 - Changes in acid-base balance during electrolytic ablation in an ex vivo perfused liver ...
500943 - Metabolic acidosis and coma due to an overdose of nalidixic acid.
19888743 - Granatumins a-g, limonoids from the seeds of a krishna mangrove, xylocarpus granatum.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-26
Journal Detail:
Title:  Head & neck     Volume:  -     ISSN:  1097-0347     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley Periodicals, Inc.
Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan; Department of Dentistry, School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intrapartum sonographic imaging of fetal head asynclitism.
Next Document:  Prediction of surgical outcome using plasma epstein-barr virus dna and (18) F-FDG PET-CT scan in rec...