Document Detail

Osteonecrosis of the jaw related to sunitinib.
MedLine Citation:
PMID:  20401503     Owner:  NLM     Status:  MEDLINE    
CASE REPORT: A 59-year-old male patient was referred to the hospital with exposed bone measuring 10 mm in diameter in the posterior, left-side region of the lower jaw. Two months previous, the first molar had been extracted. The patient had contracted renal cell carcinoma and had been treated by nephrectomy in 2003. Soft tissue metastases occurred. After initial therapy with interferon and vinblastine, a relapse occurred and the therapy was changed to sorafenib, followed by sunitinib. Osteonecrosis of the lower jaw appeared 1 year after initial and exclusive therapy with sunitinib.
CONCLUSIONS: Bisphosphonates had never been applied. With increasing application of multi-kinase inhibitors, complications due to osteonecrosis could occur more frequently.
Felix P Koch; Christian Walter; Torsten Hansen; Elke Jäger; Wilfried Wagner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral and maxillofacial surgery     Volume:  15     ISSN:  1865-1569     ISO Abbreviation:  Oral Maxillofac Surg     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-18     Completed Date:  2011-08-04     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  101319632     Medline TA:  Oral Maxillofac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  63-6     Citation Subset:  D; IM    
Oral and Maxillofacial Surgery, University Medical Centre of the Johannes Gutenberg University, Mund-, Kiefer-und Gesichtschirurgie, Mainz, Germany.
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MeSH Terms
Antineoplastic Agents / adverse effects*,  therapeutic use
Carcinoma, Renal Cell / drug therapy*,  surgery
Chemotherapy, Adjuvant
Combined Modality Therapy
Indoles / adverse effects*,  therapeutic use
Kidney Neoplasms / drug therapy*,  surgery
Mandibular Diseases / chemically induced*,  diagnosis,  surgery
Middle Aged
Molar / surgery
Neoplasm Recurrence, Local / drug therapy*,  surgery
Osteonecrosis / chemically induced*,  diagnosis,  surgery
Postoperative Complications / chemically induced,  diagnosis,  surgery
Pyrroles / adverse effects*,  therapeutic use
Tooth Extraction
Reg. No./Substance:
0/Antineoplastic Agents; 0/Indoles; 0/Pyrroles; 0/sunitinib

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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