| Osteonecrosis in children after allogeneic hematopoietic cell transplantation: study of prevalence, risk factors and longitudinal changes using MR imaging. | |
| | |
MedLine Citation:
|
PMID: 22158389 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Osteonecrosis after hematopoietic SCT (HCT) has seldom been addressed in pediatric populations. At our institution, since January 2002, children undergoing allogeneic HCT (alloHCT) receive yearly follow-up magnetic resonance imaging (MR) of hips and knees. To estimate the prevalence, longitudinal changes and associated risk factors for osteonecrosis after alloHCT, we reviewed MRs for children who underwent single alloHCT during the study period. We analyzed 149 of 344 patients who had post-HCT MR imaging performed (84 males; median age 11 years (range, 0.5-21years)), median follow-up time was 32.6 months (range, 2.8-97.2 months). In all, 44 (29.5%) developed osteonecrosis of hips and/or knees; of those, 20 (45%) had at least 30% epiphyseal involvement. In 23 (52%), osteonecrosis lesions were identified in the first and in 43 (98%) by the third yearly scan. Knees were more frequently involved than hips; severity of osteonecrosis was greater in hips. Those who had pre-alloHCT osteonecrosis, two patients' hips and six patients' knees resolved completely; three patients' osteonecrosis lesions regressed after alloHCT. On risk factor analysis, age at time of alloHCT (P=0.051) and osteonecrosis identified by MRs before alloHCT (P=0.001) were the primary risk factors. This analysis shows that preventive strategies for osteonecrosis in this population should focus on measures to minimize risk factors before alloHCT.Bone Marrow Transplantation advance online publication, 12 December 2011; doi:10.1038/bmt.2011.234. |
| | |
Authors:
|
S Sharma; W-H Leung; P Deqing; J Yang; R Rochester; L Britton; M D Neel; K K Ness; S C Kaste |
Related Documents
:
|
15987979 - Intracortical lesions in multiple sclerosis: improved detection with 3d double inversio... 740209 - Leukoencephalopathy following high-dose intravenous methotrexate chemotherapy: quantita... 18781439 - Brain integrity and cerebral atrophy in vietnam combat veterans with and without posttr... 15056239 - Periventricular low intensities on fluid attenuated inversion recovery imaging in the n... 15922309 - Changes in gray matter volume in patients with bipolar disorder. 9715229 - Adrenoleukodystrophy: unusual clinical and radiographic manifestation. 18716589 - Comparison of breath-hold and free-breathing positions of an external fiducial by analy... 17021709 - Multi-detector row ct urography on a 16-row ct scanner in the evaluation of urothelial ... 2632069 - A reticuloendothelial system-activating arabinoxylan from the bark of cinnamomum cassia. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-12 |
Journal Detail:
|
Title: Bone marrow transplantation Volume: - ISSN: 1476-5365 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8702459 Medline TA: Bone Marrow Transplant Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Radiological Sciences, St Jude Children's Research Hospital, Memphis, TN, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term follow-up of HCV-infected hematopoietic SCT patients and effects of antiviral therapy.
Next Document: [Final results from four clinical studies in the field of cardiovascular diseases integrated in the ...