| Osteomalacia as a result of vitamin d deficiency. | |
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MedLine Citation:
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PMID: 22525844 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Osteomalacia is an end-stage bone disease of chronic and severe vitamin D or phosphate depletion of any cause. Its importance has increased because of the rising incidence of vitamin D deficiency. Yet, not all cases of osteomalacia are cured by vitamin D replacement, and furthermore, not all individuals with vitamin D deficiency develop osteomalacia. Although in the past osteomalacia was commonly caused by malabsorption, nutritional deficiency now is more common. In addition, recent literature suggests that nutritional vitamin D deficiency osteomalacia follows various bariatric surgeries for morbid obesity. Bone pain, tenderness, muscle weakness, and difficulty walking are all common clinical manifestations of osteomalacia. Diagnostic work-up involves biochemical assessment of vitamin D status and may also include a transiliac bone biopsy. Treatment is based on aggressive vitamin D repletion in most cases with follow-up biopsies if patients are started on antiresorptive or anabolic agents. |
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Authors:
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Arti Bhan; Ajay D Rao; D Sudhaker Rao |
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Publication Detail:
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Type: Journal Article Date: 2012-04-12 |
Journal Detail:
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Title: Rheumatic diseases clinics of North America Volume: 38 ISSN: 1558-3163 ISO Abbreviation: Rheum. Dis. Clin. North Am. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-04-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708093 Medline TA: Rheum Dis Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 81-91 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Endocrinology, Diabetes and Bone & Mineral Disorders, Henry Ford Hospital, Detroit, MI 48202, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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