Document Detail

Osteomalacia as a result of vitamin D deficiency.
MedLine Citation:
PMID:  22525844     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Osteomalacia is an end-stage bone disease of chronic and severe vitamin D or phosphate depletion of any cause. Its importance has increased because of the rising incidence of vitamin D deficiency. Yet, not all cases of osteomalacia are cured by vitamin D replacement, and furthermore, not all individuals with vitamin D deficiency develop osteomalacia. Although in the past osteomalacia was commonly caused by malabsorption, nutritional deficiency now is more common. In addition, recent literature suggests that nutritional vitamin D deficiency osteomalacia follows various bariatric surgeries for morbid obesity. Bone pain, tenderness, muscle weakness, and difficulty walking are all common clinical manifestations of osteomalacia. Diagnostic work-up involves biochemical assessment of vitamin D status and may also include a transiliac bone biopsy. Treatment is based on aggressive vitamin D repletion in most cases with follow-up biopsies if patients are started on antiresorptive or anabolic agents.
Arti Bhan; Ajay D Rao; D Sudhaker Rao
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Publication Detail:
Type:  Journal Article     Date:  2012-04-12
Journal Detail:
Title:  Rheumatic diseases clinics of North America     Volume:  38     ISSN:  1558-3163     ISO Abbreviation:  Rheum. Dis. Clin. North Am.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-06-08     Revised Date:  2014-03-27    
Medline Journal Info:
Nlm Unique ID:  8708093     Medline TA:  Rheum Dis Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-91, viii-ix     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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Grant Support
Republished from:
Endocrinol Metab Clin North Am. 2010 Jun;39(2):321-31, table of contents   [PMID:  20511054 ]

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