| Osteomalacia as a result of vitamin D deficiency. | |
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MedLine Citation:
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PMID: 20511054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Osteomalacia is an end-stage bone disease of chronic and severe vitamin D or phosphate depletion of any cause. Its importance has increased because of the rising incidence of vitamin D deficiency. Yet, not all cases of osteomalacia are cured by vitamin D replacement, and furthermore, not all individuals with vitamin D deficiency develop osteomalacia. Although in the past osteomalacia was commonly caused by malabsorption, nutritional deficiency now is more common. In addition, recent literature suggests that nutritional vitamin D deficiency osteomalacia follows various bariatric surgeries for morbid obesity. Bone pain, tenderness, muscle weakness, and difficulty walking are all common clinical manifestations of osteomalacia. Diagnostic work-up involves biochemical assessment of vitamin D status and may also include a transiliac bone biopsy. Treatment is based on aggressive vitamin D repletion in most cases with follow-up biopsies if patients are started on antiresorptive or anabolic agents. |
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Authors:
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Arti Bhan; Ajay D Rao; D Sudhaker Rao |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Endocrinology and metabolism clinics of North America Volume: 39 ISSN: 1558-4410 ISO Abbreviation: Endocrinol. Metab. Clin. North Am. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-14 Revised Date: 2012-06-04 |
Medline Journal Info:
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Nlm Unique ID: 8800104 Medline TA: Endocrinol Metab Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 321-31, table of contents Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Endocrinology, Diabetes and Bone & Mineral Disorders, Henry Ford Hospital, Detroit, MI 48202, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Bariatric Surgery / adverse effects Child Female Fractures, Bone / drug therapy Humans Incidence Mobility Limitation Muscle Weakness / diet therapy, metabolism, pathology Obesity, Morbid / surgery Osteomalacia / diagnosis, drug therapy*, etiology* Vitamin D / analysis, therapeutic use* Vitamin D Deficiency / complications* Young Adult |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D |
| Comments/Corrections | |
Republished in:
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Rheum Dis Clin North Am. 2012 Feb;38(1):81-91, viii-ix
[PMID:
22525844
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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