Document Detail


Osteomalacia as a result of vitamin D deficiency.
MedLine Citation:
PMID:  20511054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Osteomalacia is an end-stage bone disease of chronic and severe vitamin D or phosphate depletion of any cause. Its importance has increased because of the rising incidence of vitamin D deficiency. Yet, not all cases of osteomalacia are cured by vitamin D replacement, and furthermore, not all individuals with vitamin D deficiency develop osteomalacia. Although in the past osteomalacia was commonly caused by malabsorption, nutritional deficiency now is more common. In addition, recent literature suggests that nutritional vitamin D deficiency osteomalacia follows various bariatric surgeries for morbid obesity. Bone pain, tenderness, muscle weakness, and difficulty walking are all common clinical manifestations of osteomalacia. Diagnostic work-up involves biochemical assessment of vitamin D status and may also include a transiliac bone biopsy. Treatment is based on aggressive vitamin D repletion in most cases with follow-up biopsies if patients are started on antiresorptive or anabolic agents.
Authors:
Arti Bhan; Ajay D Rao; D Sudhaker Rao
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Endocrinology and metabolism clinics of North America     Volume:  39     ISSN:  1558-4410     ISO Abbreviation:  Endocrinol. Metab. Clin. North Am.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-14     Revised Date:  2012-06-04    
Medline Journal Info:
Nlm Unique ID:  8800104     Medline TA:  Endocrinol Metab Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-31, table of contents     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Division of Endocrinology, Diabetes and Bone & Mineral Disorders, Henry Ford Hospital, Detroit, MI 48202, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bariatric Surgery / adverse effects
Child
Female
Fractures, Bone / drug therapy
Humans
Incidence
Mobility Limitation
Muscle Weakness / diet therapy,  metabolism,  pathology
Obesity, Morbid / surgery
Osteomalacia / diagnosis,  drug therapy*,  etiology*
Vitamin D / analysis,  therapeutic use*
Vitamin D Deficiency / complications*
Young Adult
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D
Comments/Corrections
Republished in:
Rheum Dis Clin North Am. 2012 Feb;38(1):81-91, viii-ix   [PMID:  22525844 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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