Document Detail

Osteogenic response of human adipose-derived stem cells to BMP-6, VEGF, and combined VEGF plus BMP-6 in vitro.
MedLine Citation:
PMID:  23017019     Owner:  NLM     Status:  In-Data-Review    
Exogenous addition of three factors-mesenchymal stem cells (MSCs), vascular endothelial growth factor (VEGF), and bone morphogenetic proteins (BMPs)-has proven to be more beneficial than delivery of any single factor for fracture repair in animal models. We studied the osteogenic differentiation of human adipose-derived stem cells (hADSCs) in the presence of VEGF, BMP-6, or VEGF plus BMP-6 to better understand their enhancement of osteoblastic differentiation of MSCs. The VEGF plus BMP-6 group demonstrated an additive effect on the enhancement of mineralization and expression of ALP and Msx2 genes. Unlike VEGF or BMP-6 alone, the combination of VEGF and BMP-6 significantly enhanced the expression of COL1A1, osterix, and Dlx5 genes. The data indicate that a cross-talk between VEGF and BMP-6 signaling pathways enhances osteogenic differentiation of hADSCs.
Yi Zhang; Vedavathi Madhu; Abhijit S Dighe; James N Irvine; Quanjun Cui
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Growth factors (Chur, Switzerland)     Volume:  30     ISSN:  1029-2292     ISO Abbreviation:  Growth Factors     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000468     Medline TA:  Growth Factors     Country:  England    
Other Details:
Languages:  eng     Pagination:  333-43     Citation Subset:  IM    
Department of Orthopaedic Surgery, University of Virginia , Charlottesville, VA , USA.
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