| Osteogenic response of human adipose-derived stem cells to BMP-6, VEGF, and combined VEGF plus BMP-6 in vitro. | |
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MedLine Citation:
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PMID: 23017019 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Exogenous addition of three factors-mesenchymal stem cells (MSCs), vascular endothelial growth factor (VEGF), and bone morphogenetic proteins (BMPs)-has proven to be more beneficial than delivery of any single factor for fracture repair in animal models. We studied the osteogenic differentiation of human adipose-derived stem cells (hADSCs) in the presence of VEGF, BMP-6, or VEGF plus BMP-6 to better understand their enhancement of osteoblastic differentiation of MSCs. The VEGF plus BMP-6 group demonstrated an additive effect on the enhancement of mineralization and expression of ALP and Msx2 genes. Unlike VEGF or BMP-6 alone, the combination of VEGF and BMP-6 significantly enhanced the expression of COL1A1, osterix, and Dlx5 genes. The data indicate that a cross-talk between VEGF and BMP-6 signaling pathways enhances osteogenic differentiation of hADSCs. |
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Authors:
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Yi Zhang; Vedavathi Madhu; Abhijit S Dighe; James N Irvine; Quanjun Cui |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Growth factors (Chur, Switzerland) Volume: 30 ISSN: 1029-2292 ISO Abbreviation: Growth Factors Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-09-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9000468 Medline TA: Growth Factors Country: England |
Other Details:
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Languages: eng Pagination: 333-43 Citation Subset: IM |
Affiliation:
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Department of Orthopaedic Surgery, University of Virginia , Charlottesville, VA , USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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