Document Detail

Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis.
MedLine Citation:
PMID:  16506027     Owner:  NLM     Status:  MEDLINE    
We randomly assigned 17 patients with scaphoid non-union at the proximal pole to three treatment groups: (1) autologous iliac graft (n=6), (2) autologous iliac graft + osteogenic protein-1 (OP-1; n=6), and (3) allogenic iliac graft + OP-1 (n=5). Radiographic, scintigraphic, and clinical assessments were performed throughout the follow-up period of 24 months. OP-1 improved the performance of both autologous and allogenic bone implants and reduced radiographic healing time to 4 weeks compared with 9 weeks in group 1. Helical CT scans and scintigraphy showed that in OP-1-treated patients sclerotic bone was replaced by well-vascularised bone. The addition of OP-1 to allogenic bone implant equalised the clinical outcome with the autologous graft procedure. Consequently the harvesting of autologous graft can be avoided.
R Bilic; P Simic; M Jelic; R Stern-Padovan; D Dodig; H Pompe van Meerdervoort; S Martinovic; D Ivankovic; M Pecina; S Vukicevic
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-02-28
Journal Detail:
Title:  International orthopaedics     Volume:  30     ISSN:  0341-2695     ISO Abbreviation:  Int Orthop     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-24     Completed Date:  2006-09-28     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7705431     Medline TA:  Int Orthop     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  128-34     Citation Subset:  IM    
Department of Orthopedic Surgery, School of Medicine, University of Zagreb, Salata 11, 10000, Zagreb, Croatia.
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MeSH Terms
Analysis of Variance
Bone Morphogenetic Protein 7
Bone Morphogenetic Proteins / pharmacology*
Fracture Healing / drug effects*
Fractures, Ununited / drug therapy*,  radiography,  radionuclide imaging,  surgery*
Ilium / transplantation*
Scaphoid Bone / injuries*,  radiography,  radionuclide imaging,  surgery*
Tomography, Spiral Computed
Transforming Growth Factor beta / pharmacology*
Reg. No./Substance:
0/BMP7 protein, human; 0/Bone Morphogenetic Protein 7; 0/Bone Morphogenetic Proteins; 0/Transforming Growth Factor beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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