| Osteogenic abilities of bone marrow stromal cells are not defective in patients with osteonecrosis. | |
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MedLine Citation:
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PMID: 18283456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated whether the proliferation activities and osteogenic capacities of bone marrow stromal cells (BMSCs) are depressed in patients with osteonecrosis of the femoral head (ONFH). BMSCs were isolated from fresh bone marrow of the iliac crests of 54 donors and were differentiated into osteogenic lineage in vitro. The results of 27 consecutive patients with ONFH (16 idiopathic and 11 alcohol-induced) were compared with those of 27 patients with a nonnecrotic hip disorder. The proliferative activities of BMSCs in patients with ONFH were not found to be reduced and their osteogenic capacities (alkaline phosphatase activity and calcium deposition amount) were unaltered during in vitro differentiation. Results from patients with idiopathic or alcohol-induced ONFH were similar to those of matched patients with nonnecrotic disorder. These findings suggest that the osteogenic potentials of BMSCs are not defective in patients with ONFH. |
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Authors:
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Jeong Joon Yoo; Won Seok Song; Kyung-Hoi Koo; Kang Sup Yoon; Hee Joong Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-19 |
Journal Detail:
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Title: International orthopaedics Volume: 33 ISSN: 1432-5195 ISO Abbreviation: Int Orthop Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-08 Completed Date: 2009-08-27 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 7705431 Medline TA: Int Orthop Country: Germany |
Other Details:
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Languages: eng Pagination: 867-72 Citation Subset: IM |
Affiliation:
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Department of Orthopaedic Surgery, Seoul National University College of Medicine, Seoul, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Alkaline Phosphatase / metabolism Bone Marrow Cells / pathology*, physiology Calcification, Physiologic / physiology Calcium / metabolism Cell Proliferation Cells, Cultured Female Femur Head Necrosis / metabolism, pathology* Humans Male Middle Aged Osteogenesis / physiology* Stromal Cells / pathology, physiology Young Adult |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium; EC 3.1.3.1/Alkaline Phosphatase |
| Comments/Corrections | |
Comment In:
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Int Orthop. 2010 Mar;34(3):457; author reply 459
[PMID:
20229614
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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