Document Detail


Osteogenic and Ewing sarcomas: estimation of necrotic fraction during induction chemotherapy with dynamic contrast-enhanced MR imaging.
MedLine Citation:
PMID:  12832588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dynamic contrast material-enhanced magnetic resonance (MR) images of primary osteogenic sarcoma (n = 19) and Ewing sarcoma (n = 10) were reviewed in 29 patients undergoing induction chemotherapy before surgery. Histogram distributions containing the initial slope and pharmacokinetic model parameters from individual voxels within each tumor were fitted for each patient. The histogram analysis of initial slope from the tumor correlated well with percentage necrosis as determined at pathologic examination (r = 0.60, P <.001), as did a two-compartment pharmacokinetic model (r = 0.64, P <.001). Both methods predicted tumors with clinically important degrees of necrosis (ie, > or =90%) in a large majority of cases. The ability to determine response to induction chemotherapy by means of noninvasive monitoring of necrotic fraction with perfusion MR imaging methods may provide useful prognostic information and help surgical planning.
Authors:
Jonathan P Dyke; David M Panicek; John H Healey; Paul A Meyers; Andrew G Huvos; Lawrence H Schwartz; Howard T Thaler; Paul S Tofts; Richard Gorlick; Jason A Koutcher; Douglas Ballon
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiology     Volume:  228     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-30     Completed Date:  2003-07-18     Revised Date:  2011-11-03    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, Weill Medical College of Cornell University, 1300 York Ave, Box 234, New York, NY 10021-4885, USA. jpd2001@med.cornell.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Contrast Media
Female
Humans
Image Enhancement
Magnetic Resonance Imaging*
Male
Necrosis
Osteosarcoma / drug therapy*,  pathology*
Sarcoma, Ewing's / drug therapy*,  pathology*
Grant Support
ID/Acronym/Agency:
491//Multiple Sclerosis Society; CA05826-038A1/CA/NCI NIH HHS; R01CA62556/CA/NCI NIH HHS; R01HL50139/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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