Document Detail

Osteogenesis induced by extracorporeal shockwave in treatment of delayed osteotendinous junction healing.
MedLine Citation:
PMID:  19603517     Owner:  NLM     Status:  MEDLINE    
Healing at the osteotendinous junction (OTJ) is challenging in orthopedic surgery. The present study aimed to test extracorporeal shockwave (ESW) in treatment of a delayed OTJ healing. Twenty-eight rabbits were used for establishing a delayed healing (DH) model at patella-patellar-tendon (PPT) complex after partial patellectomy for 4 weeks and then were divided into DH and ESW groups. In the ESW group, a single ESW treatment was given at postoperative week 6 to the PPT healing complex. The samples were harvested at week 8 and 12 for radiographic and histological evaluations with seven samples for each group at each time point. Micro-CT results showed that new bone volume was 1.18 +/- 0.61 mm(3) in the ESW group with no measurable new bone in the DH group at postoperative week 8. Scar tissue formed at the OTJ healing interface of the DH group, whereas ESW triggered high expression of VEGF in hypertrophic chondrocytes at week 8 and regeneration of the fibrocartilage zone at week 12 postoperatively. The accelerated osteogenesis could be explained by acceleration of endochondral ossification. In conclusion, ESW was able to induce osteogenesis at OTJ with delayed healing with enhanced endochondral ossification process and regeneration of fibrocartilage zone. These findings formed a scientific basis to potential clinical application of ESW for treatment of delayed OTJ healing.
Ling Qin; Lin Wang; Margaret Wan-nar Wong; Chunyi Wen; Gang Wang; Ge Zhang; Kai-ming Chan; Wing-hoi Cheung; Kwok-sui Leung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  28     ISSN:  1554-527X     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  70-6     Citation Subset:  IM    
Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, N.T. Hong Kong SAR, China.
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MeSH Terms
Chondrocytes / pathology
Disease Models, Animal
Fibrocartilage / pathology
Fractures, Bone / physiopathology,  therapy*
High-Energy Shock Waves / therapeutic use*
Neovascularization, Physiologic
Patella / blood supply,  injuries,  pathology
Patellar Ligament / blood supply,  injuries,  pathology
Tendon Injuries / physiopathology,  therapy*
Treatment Outcome
Wound Healing*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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