Document Detail

Osteogenesis imperfecta: lifelong management is imperative and feasible.
MedLine Citation:
PMID:  11324928     Owner:  NLM     Status:  MEDLINE    
Osteogenesis imperfecta is a group of inherited diseases responsible for varying degrees of skeletal fragility. Minimal trauma is sufficient to cause fractures and bone deformities. The classification of osteogenesis imperfecta has recently been improved by the inclusion of additional clinical and histomorphometric data. The diagnosis is often readily made in infancy; some cases, however, go unrecognized until adulthood. Lifelong multidisciplinary management is imperative. Pamidronate therapy in childhood is the most extensively studied treatment and has been proved beneficial. Other bisphosphonates are being evaluated, particularly in adults. Prevention of vitamin D and calcium deficiency is essential throughout life. Pain is common and should be given adequate attention.
G Chevrel; P J Meunier
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Joint, bone, spine : revue du rhumatisme     Volume:  68     ISSN:  1297-319X     ISO Abbreviation:  Joint Bone Spine     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-27     Completed Date:  2001-09-06     Revised Date:  2006-10-11    
Medline Journal Info:
Nlm Unique ID:  100938016     Medline TA:  Joint Bone Spine     Country:  France    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Service de rhumatologie et de pathologie osseuse, h pital Edouard-Herriot, Lyon, France.
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MeSH Terms
Diphosphonates / therapeutic use*
Long-Term Care
Osteogenesis Imperfecta / diagnosis,  drug therapy*
Reg. No./Substance:

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