| Osteoconductive phosphoserine-modified poly({varepsilon}-lysine) dendrons: synthesis, titanium oxide surface functionalization and response of osteoblast-like cell lines. | |
| | |
MedLine Citation:
|
PMID: 23193106 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The lack of direct bonding between the surface of an implant and the mineralized bony tissue is among the main causes of aseptic loosening in titanium-based implants. Surface etching and ceramic coatings have led to improved osteointegration, but their clinical performance is still limited either by partial bonding or by coating delamination. In this work, a solid-phase synthesis method has been optimized to produce poly(ε-lysine) dendrons, the outermost branching generation of which is functionalized by phosphoserine (PS), a known catalyst of the biomineralization process. The dendrons were deposited onto etched titanium oxide surfaces as a near-to-monolayer film able to induce the formation of a homogeneous calcium phosphate phase in a simulated body fluid over 3 days. The dendron films also stimulated MG63 and SAOS-2 osteoblast-like cells to proliferate at a rate significantly higher than etched titanium, with SAOS-2 also showing a higher degree of differentiation over 14 days. PS-tethered dendron films were not affected by various sterilization methods and UV treatment appeared to improve the cell substrate potential of these films, thus suggesting their potential as a surface functionalization method for bone implants. |
| | |
Authors:
|
S T Meikle; G Bianchi; G Olivier; M Santin |
Related Documents
:
|
23053806 - Formation of a nano-pattering niti surface with ni-depleted superficial layer to promot... 23477906 - Preimplantation human blastocysts release factors that differentially alter human endom... 22666766 - Effect of nd:yag laser combined with fluoride on the prevention of primary tooth enamel... 9445236 - Local radiant heating increases subcutaneous oxygen tension. 22256116 - Development of cost-effective biocompatible packaging for microelectronic devices. 14528776 - Bond strengths of dyract ap compomer material to dentin of permanent and primary molars... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the Royal Society, Interface / the Royal Society Volume: 10 ISSN: 1742-5662 ISO Abbreviation: J R Soc Interface Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2012-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101217269 Medline TA: J R Soc Interface Country: England |
Other Details:
|
Languages: eng Pagination: 20120765 Citation Subset: IM |
Affiliation:
|
Brighton Studies in Tissue-mimicry and Aided Regeneration, School of Pharmacy and Biomolecular Sciences, University of Brighton, , Huxley Building, Lewes Road, Brighton BN2 4GJ, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Design, purification and characterization of a soluble variant of the integral membrane protein MotB...
Next Document: On the role of lateral stabilization during early patterning in the pancreas.