| Osteoclasts and osteoblasts migrate in opposite directions in response to a constant electrical field. | |
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MedLine Citation:
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PMID: 3782308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have investigated in vitro the effects of the electrical field produced by constant current on freshly isolated rabbit osteoclasts and on well characterized clonal rat osteoblastlike cells. At field strengths of 0.1 and 1 V/mm, the osteoclasts migrated rapidly toward the positive electrode, whereas the osteoblastlike cells migrated in the opposite direction, toward the negative electrode. Thus, different cell types from the same tissue can respond differently to the same electrical signal. These results have important implications for hypotheses concerning the cellular mechanism of galvanotaxis, and may also clarify the cellular basis of the clinical application of electrical stimulation of bone healing. |
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Authors:
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J Ferrier; S M Ross; J Kanehisa; J E Aubin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cellular physiology Volume: 129 ISSN: 0021-9541 ISO Abbreviation: J. Cell. Physiol. Publication Date: 1986 Dec |
Date Detail:
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Created Date: 1987-01-12 Completed Date: 1987-01-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0050222 Medline TA: J Cell Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 283-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cell Movement Electricity* Electrodes Embryo, Mammalian Osteoblasts / cytology* Osteoclasts / cytology* Rabbits Rats Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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