Document Detail

Osteoclast-type giant cell tumor of minor salivary gland with mucin-rich salivary duct carcinoma: a case report of unusual histology with immunohistochemical analysis.
MedLine Citation:
PMID:  20346712     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Salivary giant cell tumor (GCT) is exceedingly rare. This article presents an additional rare case of salivary GCT with salivary duct carcinoma (SDC).
STUDY DESIGN AND RESULTS: The patient was a 40-year-old Japanese male. The peripheral region of the tumor showed SDC and partly revealed a mucin accumulation with cancer nests, which was a mucin-rich variant of SDC. In the central region of the tumor, mononuclear ovoid tumor cells contained osteoclastic-type giant cells. SDC showed immunopositivity for gross cystic disease fluid protein-15 (GCDFP-15), androgen receptor (AR), and Her-2, whereas the giant cell lesion was negative for GCDFP-15, AR, and Her-2. Mononuclear cells in salivary GCT showed immunopositivity for epithelial membrane antigen and p53.
CONCLUSION: The salivary GCT was thought to be neoplastic and derived from epithelial cells. The present case is the first de novo case of intraoral salivary GCT with a mucin-rich variant of SDC.
Kimihide Kusafuka; Satoshi Nakamura; Rie Asano; Tomoyuki Kamijo; Yoshiyuki Iida; Tetsuro Onistuka; Takashi Nakajima
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-03-25
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics     Volume:  109     ISSN:  1528-395X     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-18     Revised Date:  2011-08-25    
Medline Journal Info:
Nlm Unique ID:  9508562     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  870-7     Citation Subset:  D; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan.
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MeSH Terms
Carcinoma, Ductal / metabolism,  pathology*,  surgery
Giant Cell Tumors / metabolism,  pathology*,  surgery
Mucins / metabolism
Neoplasms, Complex and Mixed / metabolism,  pathology*,  surgery
Osteoclasts / pathology
Rare Diseases
Salivary Ducts / pathology*,  surgery
Salivary Gland Neoplasms / metabolism,  pathology*,  surgery
Salivary Glands, Minor / metabolism,  pathology,  surgery
Salivary Proteins and Peptides / metabolism
Treatment Outcome
Reg. No./Substance:
0/Mucins; 0/Salivary Proteins and Peptides

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