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Osteochondral Defects of the Talus: a Novel Animal Model in the Goat.
MedLine Citation:
PMID:  23136872     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Osteochondral defects of the talus pose a difficult therapeutic challenge. An experimental animal model of the ankle joint is not available. The aim of this study was to test a newly developed animal model for osteochondral defects of the ankle in vivo. Osteochondral defects were created in the talus of goat hind legs using a posterolateral surgical approach. The defects were filled with either autologous cancellous bone or donor demineralized bone matrix, or left empty as control. After 12 weeks of healing, the specimens were analyzed with radiography, macroscopy, micro-computed tomography, histology, histomorphometry, and fluorescence microscopy. It was possible to create a standardized defect in each talus. The implanted material remained in place. The analyses showed that most bony tissue was generated in the defects filled with autologous bone and least in the control defects. Our findings show that a standard osteochondral defect can be created in the talus by a relatively simple procedure in a large animal that allows qualitative and quantitative evaluation. The model can be used in future experiments to investigate alternative treatment methods before they are introduced into clinical practice.
Authors:
Christiaan J A van Bergen; Gino M M J Kerkhoffs; Nick Marsidi; Clara M Korstjens; Vincent Everts; Leo J van Ruijven; C Niek van Dijk; Leendert Blankevoort
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Tissue engineering. Part C, Methods     Volume:  -     ISSN:  1937-3392     ISO Abbreviation:  Tissue Eng Part C Methods     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101466663     Medline TA:  Tissue Eng Part C Methods     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Academic Medical Center, Orthopaedic Surgery, Meibergdreef 9, Amsterdam, Netherlands, 1078 CE, +31205669111; c.j.vanbergen@amc.nl.
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