Document Detail

Osteochemonecrosis: an overview.
MedLine Citation:
PMID:  25409847     Owner:  NLM     Status:  In-Data-Review    
Osteonecrosis of the jaw to a certain extent has been with us for many years. But recently the advent of various medications such as bisphosphonates, VEGF inhibitors, tyrosine kinase inhibitors and humanized antibodies to osteoclastic action have resulted in thousands of cases. While the bisphosphonates continue to be the most common medication associated with osteochemonecrosis antibodies such as denosumab which irreversibly act on osteoclastic action are also being reported. This narrative review will serve as an update with a focus on some of the histopathologic features discussed and reviewed. Perhaps even more uncommonly seen in past reports a discussion of features possibly observed while grossing specimens will be discussed. At the end of this report is hoped that the pathologist will have a better understanding of the historical features, clinical settings, gross examination features as well as histopathologic features associated with osteochemonecrosis.
John Hellstein
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Publication Detail:
Type:  Journal Article     Date:  2014-11-20
Journal Detail:
Title:  Head and neck pathology     Volume:  8     ISSN:  1936-0568     ISO Abbreviation:  Head Neck Pathol     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-11-27     Completed Date:  -     Revised Date:  2014-12-03    
Medline Journal Info:
Nlm Unique ID:  101304010     Medline TA:  Head Neck Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  482-90     Citation Subset:  IM    
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