Document Detail

Osteoblastic activity of the rabbit temporomandibular joint during distraction osteogenesis assessed by [18F]fluoride positron emission tomography.
MedLine Citation:
PMID:  12013558     Owner:  NLM     Status:  MEDLINE    
The purpose of the study was to evaluate the effects of irradiation and hyperbaric oxygenation (HBO) on osteoblastic activity of the temporomandibular joint (TMJ) region during mandibular distraction osteogenesis. Unilateral distraction was performed on 19 rabbits, which were divided into five groups. One group served as a control group, while the others received either high- or low-dose irradiation in the TMJ region before surgery. Some of the animals were also given HBO 18 times at 2.5 ATA x 90 min preoperatively. Osteogenesis was assessed by [18F]fluoride positron emission tomography at the end of the distraction. Osteoblastic activity was higher on the distracted side in all groups, except in the high-dose irradiated group without preceding HBO. HBO increased osteogenesis on both sides after radiotherapy. It is concluded that increased osteoblastic activity reflects increased pressure on the TMJ region of the distracted side, resulting from lengthening. It seems that more remodeling is required after irradiation than without preceding radiotherapy. After radiotherapy, HBO increased osteoblastic activity.
Arja Muhonen; Timo Peltomäki; Juhani Knuuti; Olli Raitakari; Risto-Pekka Happonen
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  European journal of oral sciences     Volume:  110     ISSN:  0909-8836     ISO Abbreviation:  Eur. J. Oral Sci.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-15     Completed Date:  2002-08-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9504563     Medline TA:  Eur J Oral Sci     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  144-8     Citation Subset:  D; IM    
Department of Oral and Maxillofacial Surgery, University of Turku, Finland.
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MeSH Terms
Analysis of Variance
Cranial Irradiation / adverse effects
Fluorine Radioisotopes / metabolism
Hyperbaric Oxygenation
Mandibular Condyle / cytology,  physiology*,  radiation effects*,  radionuclide imaging
Osteoblasts / physiology,  radiation effects
Osteogenesis / physiology,  radiation effects*
Osteogenesis, Distraction*
Radiation Injuries / therapy
Temporomandibular Joint / cytology,  physiology*,  radiation effects*,  radionuclide imaging
Tomography, Emission-Computed
Reg. No./Substance:
0/Fluorine Radioisotopes

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