Document Detail

Osteoblast response to ovariectomy is enhanced in intrinsically high aerobic-capacity rats.
MedLine Citation:
PMID:  21212941     Owner:  NLM     Status:  MEDLINE    
The role of exercise in promoting bone health is typically attributed to increased mechanical loading, which induces functional adaptation. Recent evidence suggests that habitual aerobic exercise has influence at the cellular level as well. The effect of aerobic capacity on osteoblast-lineage cell differentiation and function as well as skeletal phenotype is unknown. Using a rat model of high-capacity and low-capacity runners (HCRs and LCRs, respectively), in which an intrinsic functional genomic difference in aerobic capacity exists between nontrained animals, this study evaluated the effects of aerobic capacity on measures of bone mass and strength as well as osteoblast activity following ovariectomy. The ovariectomized rat emulates the clinical features of the estrogen-depleted human skeleton and represents a valuable model for studying short-term upregulation of osteoblast activity. We hypothesized that intrinsically high aerobic capacity would augment osteoblast response, which would mitigate the deleterious effects of hormone withdrawal. Femora and tibiae were assessed by micro-computed tomography, mechanical testing, and dynamic histomorphometry. HCRs had enhanced femoral tissue mineral density and estimated elastic modulus relative to LCRs. At 4 weeks postovariectomy, HCRs demonstrated a more robust osteoblast response. Markers of bone formation were upregulated to a greater extent in HCRs than LCRs, suggesting a role for aerobic capacity in governing osteoblast activity. Results from this and future studies will help to identify the influence of cellular aerobic metabolism on bone health, which may lead to new strategies for targeting diseases of the skeleton.
G C Goulet; N R Halonen; L G Koch; S L Britton; R F Zernicke; K M Kozloff
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-01-07
Journal Detail:
Title:  Calcified tissue international     Volume:  88     ISSN:  1432-0827     ISO Abbreviation:  Calcif. Tissue Int.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-18     Completed Date:  2011-07-15     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  7905481     Medline TA:  Calcif Tissue Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  325-35     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bone and Bones / metabolism
Exercise Tolerance
Femur / pathology
Hormones / metabolism
Models, Biological
Osteoblasts / metabolism*
Ovariectomy / methods*
Oxygen / metabolism*
Physical Conditioning, Animal
Stress, Mechanical
X-Ray Microtomography / methods
Grant Support
R24 RR017718/RR/NCRR NIH HHS; R24 RR017718-10/RR/NCRR NIH HHS; R24 RR17718/RR/NCRR NIH HHS
Reg. No./Substance:
0/Hormones; S88TT14065/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment.
Next Document:  Cortical thickness, gray matter volume, and white matter anisotropy and diffusivity in schizophrenia...