| Osteoarthritis year 2011 in review: biology. | |
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MedLine Citation:
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PMID: 22179031 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review is focused on advances in understanding the biology of joint homeostasis and osteoarthritis (OA) pathogenesis mechanisms that have led to proof of concept studies on new therapeutic approaches. The three selected topics include angiogenesis in joint tissues, biomechanics and joint lubrication and mitochondrial dysfunction. This new information represents progress in the integration of mechanisms that control multiple aspects of OA pathophysiology. |
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Authors:
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M Lotz |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-12-01 |
Journal Detail:
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Title: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society Volume: 20 ISSN: 1522-9653 ISO Abbreviation: Osteoarthr. Cartil. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-21 Completed Date: 2012-04-30 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 9305697 Medline TA: Osteoarthritis Cartilage Country: England |
Other Details:
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Languages: eng Pagination: 192-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. mlotz@scripps.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autophagy Glycoproteins / physiology Humans Hyaluronic Acid / physiology Joints / blood supply Mitochondria / pathology Mitochondrial Diseases / complications Neovascularization, Pathologic / complications Osteoarthritis / etiology*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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AG007996/AG/NIA NIH HHS; AR056026/AR/NIAMS NIH HHS; AR058954/AR/NIAMS NIH HHS; P01 AG007996-18/AG/NIA NIH HHS; R01 AR056026/AR/NIAMS NIH HHS; R01 AR056026-03/AR/NIAMS NIH HHS; RC2 AR058954-02/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/lubricin; 9004-61-9/Hyaluronic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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