Document Detail


Osteoarthritis year 2011 in review: biology.
MedLine Citation:
PMID:  22179031     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review is focused on advances in understanding the biology of joint homeostasis and osteoarthritis (OA) pathogenesis mechanisms that have led to proof of concept studies on new therapeutic approaches. The three selected topics include angiogenesis in joint tissues, biomechanics and joint lubrication and mitochondrial dysfunction. This new information represents progress in the integration of mechanisms that control multiple aspects of OA pathophysiology.
Authors:
M Lotz
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-12-01
Journal Detail:
Title:  Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society     Volume:  20     ISSN:  1522-9653     ISO Abbreviation:  Osteoarthr. Cartil.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-21     Completed Date:  2012-04-30     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9305697     Medline TA:  Osteoarthritis Cartilage     Country:  England    
Other Details:
Languages:  eng     Pagination:  192-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Autophagy
Glycoproteins / physiology
Humans
Hyaluronic Acid / physiology
Joints / blood supply
Mitochondria / pathology
Mitochondrial Diseases / complications
Neovascularization, Pathologic / complications
Osteoarthritis / etiology*,  physiopathology
Grant Support
ID/Acronym/Agency:
AG007996/AG/NIA NIH HHS; AR056026/AR/NIAMS NIH HHS; AR058954/AR/NIAMS NIH HHS; P01 AG007996/AG/NIA NIH HHS; P01 AG007996-18/AG/NIA NIH HHS; R01 AR056026/AR/NIAMS NIH HHS; R01 AR056026-03/AR/NIAMS NIH HHS; RC2 AR058954/AR/NIAMS NIH HHS; RC2 AR058954-02/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Glycoproteins; 0/lubricin; 9004-61-9/Hyaluronic Acid
Comments/Corrections

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