Document Detail

Osteoarthritis: a review of treatment options.
MedLine Citation:
PMID:  20726384     Owner:  NLM     Status:  MEDLINE    
Osteoarthritis (OA) is the most common form of arthritis and the leading cause of disability in the United States, especially among older adults. Treatment options have primarily focused on alleviating the pain often associated with this condition. Acetaminophen and nonsteroidal anti inflammatory drugs (NSAIDs) are often employed for relief of mild-to moderate pain associated with OA. NSAIDs are typically more effective than acetaminophen; however, because of adverse effects associated with long-term use of NSAIDS, acetaminophen is considered first-line therapy. Safety concerns of traditional pharmacotherapeutic agents used in the management of OA, such as NSAIDs and opioids, have led healthcare professionals to seek other options. Trials of disease modulating agents that focus on preventing further damage to the joints have the potential to change how this disease state is managed. This article reviews nonpharmacologic and pharmacologic approaches to management of OA of the knee and hip.
Sheila M Seed; Kaelen C Dunican; Ann M Lynch
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Geriatrics     Volume:  64     ISSN:  0016-867X     ISO Abbreviation:  Geriatrics     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985102R     Medline TA:  Geriatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-9     Citation Subset:  IM    
Massachusetts College of Pharmacy and Health Science, Worcester, Massachusetts, USA.
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MeSH Terms
Acetaminophen / therapeutic use
Aged, 80 and over
Analgesics, Opioid / therapeutic use
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Chondroitin Sulfates / therapeutic use
Cyclooxygenase Inhibitors / therapeutic use*
Dose-Response Relationship, Drug
Drug Interactions
Drug Therapy, Combination
Evidence-Based Medicine
Glucosamine / therapeutic use*
Osteoarthritis / complications,  drug therapy*,  epidemiology
Pain / drug therapy*,  epidemiology,  etiology
Patient Education as Topic
Risk Factors
United States / epidemiology
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase Inhibitors; 103-90-2/Acetaminophen; 3416-24-8/Glucosamine; 9007-28-7/Chondroitin Sulfates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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