Document Detail


Osteitic bone: a surrogate marker of eosinophilia in chronic rhinosinusitis.
MedLine Citation:
PMID:  22888488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Causes of osteitis in chronic rhinosinusitis (CRS) other than previous surgery are poorly defined. Patients with eosinophilic CRS (ECRS) have more severe disease and poorer outcomes despite repeated surgery. Associations between osteitis and markers of ECRS are not well described.
METHODS: A cross-sectional study of CRS patients undergoing sinus surgery was conducted. Osteitis was scored radiologically using previously published measures. Associations between osteitis and histopathology, symptoms, endoscopy, CT mucosal score and seromarkers were analyzed.
RESULTS: Eighty-eight patients were assessed of whom forty-five had osteitis. Patients undergoing revision surgery recorded higher osteitis scores. Patients with mucosal eosinophilia had higher osteitis score than those without. Patients with osteitis had higher serum eosinophil. Similar relationships were also found in primary surgery. Osteitis was associated with endoscopic and radiologic, but not symptomatic disease severity.
CONCLUSIONS: Osteitis is associated with tissue and serum eosinophilia in both patients with and without prior surgery. Patients with these features may benefit from post-operative corticosteroid therapy to prevent osteitis.
Authors:
K Snidvongs; R McLachlan; D Chin; E Pratt; R Sacks; P Earls; R J Harvey
Related Documents :
21745748 - Relationships between disk displacement, joint effusion, and degenerative changes of th...
22748488 - Cerebral blood flow as a marker for recovery of left ventricular systolic dysfunction i...
22723728 - The management of hyperphosphatemia by lanthanum carbonate in chronic kidney disease pa...
21597788 - Serum levels of scc, cea, ca-125 and tpa in the management of cervical-carcinoma.
1734288 - Clinical and eeg features of status epilepticus in comatose patients.
23270828 - Phlebosclerosis in lower extremities veins.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rhinology     Volume:  50     ISSN:  0300-0729     ISO Abbreviation:  Rhinology     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-13     Completed Date:  2013-02-12     Revised Date:  2013-06-15    
Medline Journal Info:
Nlm Unique ID:  0347242     Medline TA:  Rhinology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  299-305     Citation Subset:  IM    
Affiliation:
Macquarie University, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Chronic Disease
Cross-Sectional Studies
Eosinophilia / complications*,  diagnosis
Female
Humans
Male
Middle Aged
Osteitis / blood,  complications*,  diagnosis
Rhinitis / blood,  complications*,  pathology*
Severity of Illness Index
Sinusitis / blood,  complications*,  pathology*
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nasal dysfunction induced by chlorinate water in competitive swimmers.
Next Document:  A double-blind randomised controlled trial of gloved versus ungloved merocel middle meatal spacers f...