Document Detail

Osteitic bone: a surrogate marker of eosinophilia in chronic rhinosinusitis.
MedLine Citation:
PMID:  22888488     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Causes of osteitis in chronic rhinosinusitis (CRS) other than previous surgery are poorly defined. Patients with eosinophilic CRS (ECRS) have more severe disease and poorer outcomes despite repeated surgery. Associations between osteitis and markers of ECRS are not well described.
METHODS: A cross-sectional study of CRS patients undergoing sinus surgery was conducted. Osteitis was scored radiologically using previously published measures. Associations between osteitis and histopathology, symptoms, endoscopy, CT mucosal score and seromarkers were analyzed.
RESULTS: Eighty-eight patients were assessed of whom forty-five had osteitis. Patients undergoing revision surgery recorded higher osteitis scores. Patients with mucosal eosinophilia had higher osteitis score than those without. Patients with osteitis had higher serum eosinophil. Similar relationships were also found in primary surgery. Osteitis was associated with endoscopic and radiologic, but not symptomatic disease severity.
CONCLUSIONS: Osteitis is associated with tissue and serum eosinophilia in both patients with and without prior surgery. Patients with these features may benefit from post-operative corticosteroid therapy to prevent osteitis.
K Snidvongs; R McLachlan; D Chin; E Pratt; R Sacks; P Earls; R J Harvey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rhinology     Volume:  50     ISSN:  0300-0729     ISO Abbreviation:  Rhinology     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-13     Completed Date:  2013-02-12     Revised Date:  2013-06-15    
Medline Journal Info:
Nlm Unique ID:  0347242     Medline TA:  Rhinology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  299-305     Citation Subset:  IM    
Macquarie University, Australia.
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MeSH Terms
Biological Markers / blood
Chronic Disease
Cross-Sectional Studies
Eosinophilia / complications*,  diagnosis
Middle Aged
Osteitis / blood,  complications*,  diagnosis
Rhinitis / blood,  complications*,  pathology*
Severity of Illness Index
Sinusitis / blood,  complications*,  pathology*
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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