Document Detail

Ossification sequence in infants who die during the perinatal period: population-based references.
MedLine Citation:
PMID:  12355011     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine population-based references for the relationships between the presence of ossification centers and gestational age and skeletal length measurements among infants who die during the perinatal period, as well as to evaluate the possible influence of intrauterine growth restriction on ossification stage. MATERIALS AND METHODS: During an 11-year period, nearly all infants who died perinatally in a well-defined geographic area routinely underwent radiography with a standardized technique. The presence of visible secondary ossification centers in the singletons (n = 495) was evaluated. Cluster analysis was used to identify stages of ossification; a sequential appearance of secondary ossification centers was assumed. Comparisons were made with Wilks lambda between male and female infants and between infants who were presumed to have growth restriction and those who were not. Reference ranges for the presence of ossification centers were calculated for interquartile ranges of femur length and gestational age. RESULTS: Eight clusters of ossification defining different stages of ossification of the pelvis, hindfeet, and knees were identified. The sequential clusters outlined well-defined intervals of femur length and gestational age. Bone lengths, birth weight, and gestational age within ossification clusters did not differ between the sexes (Wilks lambda = 0.989, P =.532) or according to whether growth restriction was presumed to exist (Wilks lambda = 0.958, P =.481). CONCLUSION: The reference diagrams calculated with this method indicate relationships between ossification sequence and both gestational age and skeletal length measurements.
Øystein E Olsen; Rolv T Lie; Ralph S Lachman; Helga Maartmann-Moe; Karen Rosendahl
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Radiology     Volume:  225     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-30     Completed Date:  2002-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  240-4     Citation Subset:  AIM; IM    
Department of Radiology, Haukeland University Hospital, Bergen, Norway.
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MeSH Terms
Birth Weight
Bone and Bones / embryology,  radiography*
Fetal Death / radiography
Fetal Growth Retardation / radiography
Fetus / radiography*
Foot Bones / embryology,  radiography
Gestational Age
Infant, Newborn
Infant, Newborn, Diseases / mortality
Knee Joint / embryology,  radiography
Pelvic Bones / embryology,  radiography

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