Document Detail

Osseous sarcoidosis treated with tumor necrosis factor-inhibitors: case report and review of the literature.
MedLine Citation:
PMID:  21381234     Owner:  NLM     Status:  MEDLINE    
STUDY DESIGN: Report of 2 cases of sarcoidosis involving vertebrae successfully treated with tumor necrosis factor-α inhibitor (TNF-α antagonist).
OBJECTIVE: To disseminate knowledge concerning successful treatment of sarcoidosis involving the axial skeleton with the use of TNF-α blockers.
SUMMARY OF BACKGROUND DATA: Osseous sarcoidosis most commonly involves small bones of hands and feet; vertebral involvement is rare, and currently there is no consensus on optimal treatment.
METHODS: Two cases are described detailing patients with extrapulmonary sarcoidosis involving vertebral bodies, retractable to conventional treatment, who were treated with TNF-α antagonists.
RESULTS: We observed a remarkable response following the administration of TNF-α blockers in vertebral sarcoidosis with marked resolution of lytic lesions. The patients remained asymptomatic with no recurrence of their disease.
CONCLUSION: Vertebral sarcoidosis is a rare manifestation of osseous sarcoidosis. Symptomatic patients are treated with various immunosuppressive therapies. We propose utilizing TNF-α blocking agents in patients who fail to respond to first-line therapy.
Sarfaraz A Hasni; Daniel Kunz; Kathleen Finzel; Barry L Gruber
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Spine     Volume:  35     ISSN:  1528-1159     ISO Abbreviation:  Spine     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2011-03-04     Completed Date:  2012-01-11     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  7610646     Medline TA:  Spine (Phila Pa 1976)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E904-7     Citation Subset:  IM    
Stony Brook University Medical Center, Stony Brook, NY 11794, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Antibodies, Monoclonal / administration & dosage
Antibodies, Monoclonal, Humanized / administration & dosage
Middle Aged
Sarcoidosis / drug therapy*,  pathology,  radiography
Spinal Diseases / drug therapy*,  pathology,  radiography
Spine / drug effects*,  pathology,  radiography
Tumor Necrosis Factor-alpha / antagonists & inhibitors*,  immunology*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Tumor Necrosis Factor-alpha; 0/infliximab; FYS6T7F842/adalimumab

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