Document Detail

Osseointegration in arthroplasty: can simvastatin promote bone response to implants?
MedLine Citation:
PMID:  18157535     Owner:  NLM     Status:  MEDLINE    
Cementless fixation depends on bone ingrowth for long-term success. Simvastatin as a lipid lowering agent has been demonstrated to have osteoanabolic effects. This study was designed to measure the possible effect of simvastatin on implant osseointegration. Bilateral femoral implantation of titanium cylinders was performed in 20 rabbits. Blood lipid levels were measured pre- and postoperatively. Scanning electron microscopy (SEM) was used to measure the percentage of the surface of each implant in contact with bone and mechanical pull-out testing was performed. The blood lipid levels were significantly reduced in the simvastatin group. Histomorphometric examination revealed increased bone ingrowth and mechanical examination showed increased interface strength in the simvastatin group. Mechanical and histological data showed superior stability and osseous adaptation at the bone/implant interface for the simvastatin group. We conclude that simvastatin has potential as a means of enhancing bone ingrowth, which is a key factor in the longevity of cementless implants.
Kerem Başarir; Bülent Erdemli; Alp Can; Esra Erdemli; Tuğba Zeyrek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-21
Journal Detail:
Title:  International orthopaedics     Volume:  33     ISSN:  1432-5195     ISO Abbreviation:  Int Orthop     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-08-27     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  7705431     Medline TA:  Int Orthop     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  855-9     Citation Subset:  IM    
Department of Orthopaedic Surgery, Ankara University School of Medicine, Ankara, Turkey.
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MeSH Terms
Antilipemic Agents / pharmacology*
Arthroplasty, Replacement / methods*
Femur / drug effects,  ultrastructure
Implants, Experimental
Lipids / blood
Materials Testing / methods*
Microscopy, Electron, Scanning
Models, Animal
Osseointegration / drug effects*,  physiology
Osteogenesis / drug effects*,  physiology
Simvastatin / pharmacology*
Reg. No./Substance:
0/Antilipemic Agents; 0/Lipids; 79902-63-9/Simvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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