Document Detail


Osmotic shock induces the presence of glycocardiolipin in the purple membrane of Halobacterium salinarum.
MedLine Citation:
PMID:  12923225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the purple membrane (PM) of Halobacterium salinarum is present a phospholipid dimer consisting of sulfo-triglycosyl-diether (S-TGD-1) esterified to the phosphate group of phosphatidic acid (PA), i.e., S-TGD-1-PA, called glycocardiolipin (GlyC) (Corcelli, A., M. Colella, G. Mascolo, F. P. Fanizzi, and M. Kates. A novel glycolipid and phospholipid in the purple membrane. 2000. Biochemistry. 39: 3318-3326). The GlyC content of whole cells, PM, and other cell fractions of H. salinarum have been analyzed. GlyC is a nonabundant phospholipid in H. salinarum cells, and it represents one of the major phospholipids of isolated PM. In this report, we show that a) GlyC is formed during the isolation of PM, b) GlyC increase in H. salinarum cells is specifically induced by osmotic shock, and c) in correspondence with GlyC increase, a decrease of S-TGD-1 levels occurs. The changes in membrane lipid composition observed during the isolation of PM are due to de novo synthesis of GlyC from S-TGD-1.
Authors:
Simona Lobasso; Patrizia Lopalco; Veronica M T Lattanzio; Angela Corcelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-08-16
Journal Detail:
Title:  Journal of lipid research     Volume:  44     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-24     Completed Date:  2004-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2120-6     Citation Subset:  IM    
Affiliation:
Dipartimento di Fisiologia Generale ed Ambientale and Dipartimento di Chimica, Università di Bari, via Amendola 165/a, 70126 Bari, Italy.
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MeSH Terms
Descriptor/Qualifier:
Cardiolipins / biosynthesis*,  chemistry
Chromatography, Thin Layer
Halobacterium salinarum / cytology,  metabolism*
Lipid Metabolism
Molecular Structure
Osmotic Pressure
Purple Membrane / metabolism*
Chemical
Reg. No./Substance:
0/Cardiolipins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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