Document Detail


Osmotic Swelling Pressure Response of Smart Hydrogels Suitable for Chronically-Implantable Glucose Sensors.
MedLine Citation:
PMID:  20161690     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In the last few years, a new type of glucose-sensitive hydrogel (GSH) has been developed that shrinks with increasing glucose concentration due to the formation of reversible crosslinks The first osmotic swelling pressure results measured for any member of this new class of GSH are reported, so that their suitability for use in sensors combining pressure transducers and smart gels can be evaluated. Comparison is also made with results obtained for an older type of GSH that expands with increasing glucose concentration due to an increase in the concentration of counterions within the gel. The newer type of GSH exhibits both faster kinetics and weaker fructose interference, and therefore is more suitable for in vivo glucose sensing.
Authors:
G Lin; S Chang; H Hao; P Tathireddy; M Orthner; J Magda; F Solzbacher
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Sensors and actuators. B, Chemical     Volume:  144     ISSN:  0925-4005     ISO Abbreviation:  -     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101149755     Medline TA:  Sens Actuators B Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  332     Citation Subset:  -    
Affiliation:
Department of Materials Science & Engineering, University of Utah, Salt Lake City, Utah 84112 USA.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R21 EB008571-02//NIBIB NIH HHS

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