Document Detail


Osmosignaling and volume regulation in intestinal epithelial cells.
MedLine Citation:
PMID:  17875427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Most cells have to perform their physiological functions under a variable osmotic stress, which, because of the relatively high permeability of the plasma membrane for water, may result in frequent alterations in cell size. Intestinal epithelial cells are especially prone to changes in cell volume because of their high capacity of salt and water transport and the high membrane expression of various nutrient transporters. Therefore, to avoid excessive shrinkage or swelling, enterocytes, like most cell types, have developed efficient mechanisms to maintain osmotic balance. This chapter reviews selected model systems that can be used to investigate cell volume regulation in intestinal epithelial cells, with emphasis on the regulatory volume decrease, and the methods available to study the compensatory redistribution of (organic) osmolytes. In addition, a brief summary is presented of the pathways involved in osmosensing and osmosignaling in the intestine.
Authors:
Christina H Lim; Alice G M Bot; Hugo R de Jonge; Ben C Tilly
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Methods in enzymology     Volume:  428     ISSN:  0076-6879     ISO Abbreviation:  Meth. Enzymol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-09-18     Completed Date:  2007-11-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0212271     Medline TA:  Methods Enzymol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  325-42     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Erasmus University Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Physiological Phenomena
Cell Size
Enterocytes / physiology*
Humans
Ion Channels / physiology
Models, Animal
Osmotic Pressure*
Patch-Clamp Techniques
Radioisotopes / diagnostic use
Signal Transduction / physiology
Chemical
Reg. No./Substance:
0/Ion Channels; 0/Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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