Document Detail

Osmosensitive mechanisms contribute to the water drinking-induced pressor response in humans.
MedLine Citation:
PMID:  16186532     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Water drinking elicits a sympathetically mediated pressor response in multiple-system atrophy patients through an unknown mechanism. We reasoned that gastrointestinal distention, hyposomotic stimulation, or both contribute to the water-induced pressor response. METHODS: We compared the response to normal saline and water on blood pressure in 10 patients with probable multiple-system atrophy. Patients featured moderate to severe autonomic dysfunction. EKG and finger arterial blood pressure were recorded continuously, and 500 mL normal saline and distilled water were each given in a single-blinded fashion. Fluids were applied through a previously inserted nasogastric tube within a 5-minute period. RESULTS: Blood pressure began to increase within 10 minutes after water administration and reached a maximum after 20 minutes. Blood pressure did not change after saline administration. The blood pressure change after 20 minutes was 8 +/- 9/2 +/- 5 mmHg with water and -1 +/- 11/-1 +/- 7 mmHg with normal saline administration (p = 0.02 between interventions). Heart rate did not change with either intervention. CONCLUSION: Ingestion of water elicits a greater pressor response than the ingestion of normal saline. Thus, gastric distention is probably not the crucial mechanisms for the water-induced pressor response. Instead, the response may be mediated through osmosensitive afferent structures in the gastrointestinal tract, portal vein, and liver.
A Lipp; J Tank; G Franke; G Arnold; F C Luft; J Jordan
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neurology     Volume:  65     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-27     Completed Date:  2006-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  905-7     Citation Subset:  AIM; IM    
Department of Neurology, Medical University Charité, Berlin, Germany.
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MeSH Terms
Autonomic Nervous System Diseases / physiopathology*
Blood Pressure / drug effects,  physiology*
Gastrointestinal Tract / innervation,  physiology
Liver / innervation,  physiology
Models, Neurological
Multiple System Atrophy / physiopathology*
Portal Vein / innervation,  physiology
Sodium Chloride / pharmacology
Vasoconstriction / drug effects,  physiology*
Visceral Afferents / drug effects,  physiology
Water / pharmacology
Water-Electrolyte Balance / drug effects,  physiology*
Reg. No./Substance:
7647-14-5/Sodium Chloride; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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