Document Detail

Osmosensing by bacteria.
MedLine Citation:
PMID:  17047223     Owner:  NLM     Status:  MEDLINE    
Osmosensors are proteins that sense environmental osmotic pressure. They mediate or direct osmoregulatory responses that allow cells to survive osmotic changes and extremes. Bacterial osmosensing transporters sense high external osmotic pressure and respond by mediating organic osmolyte uptake, hence cellular rehydration. Detailed studies of osmosensing transporters OpuA, BetP, and ProP suggest that they sense and respond to different osmotic pressure-dependent cellular properties. These studies also suggest that each protein has a cytoplasmic osmosensory or osmoregulatory domain, but that these domains differ in structure and function. It is not yet clear whether each transporter represents a distinct osmosensory mechanism or whether different research groups are approaching the same mechanism by way of different paths. Principles emerging from this research will apply to other osmosensors, including those that initiate signal transduction cascades in prokaryotes and eukaryotes.
Janet M Wood
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-10-17
Journal Detail:
Title:  Science's STKE : signal transduction knowledge environment     Volume:  2006     ISSN:  1525-8882     ISO Abbreviation:  Sci. STKE     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-18     Completed Date:  2006-12-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100964423     Medline TA:  Sci STKE     Country:  United States    
Other Details:
Languages:  eng     Pagination:  pe43     Citation Subset:  IM    
Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
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MeSH Terms
ATP-Binding Cassette Transporters / physiology*
Adenosine Triphosphatases / physiology*
Aquaporins / physiology
Bacterial Physiological Phenomena*
Bacterial Proteins / chemistry,  physiology*
Betaine / metabolism
Carrier Proteins / chemistry,  physiology*
Cation Transport Proteins / physiology
Corynebacterium glutamicum / chemistry,  physiology
Electrolytes / pharmacology
Escherichia coli / physiology
Escherichia coli Proteins / chemistry,  physiology*
Glutamic Acid / metabolism
Lactococcus lactis / physiology
Membrane Proteins / physiology
Models, Biological
Osmotic Pressure*
Polyethylene Glycols / pharmacology
Potassium / pharmacology
Proteolipids / metabolism
Signal Transduction / physiology*
Symporters / chemistry,  physiology*
Water / metabolism
Reg. No./Substance:
0/ATP-Binding Cassette Transporters; 0/Aquaporins; 0/Bacterial Proteins; 0/BetP protein, Corynebacterium glutamicum; 0/Carrier Proteins; 0/Cation Transport Proteins; 0/Electrolytes; 0/Escherichia coli Proteins; 0/Membrane Proteins; 0/Polyethylene Glycols; 0/ProP protein, E coli; 0/Proteolipids; 0/Symporters; 0/aqpZ protein, E coli; 0/proteoliposomes; 107-43-7/Betaine; 56-86-0/Glutamic Acid; 7440-09-7/Potassium; 7732-18-5/Water; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/potassium translocating Kdp-ATPase, E coli; EC protein, Lactococcus lactis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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