Document Detail

Oseltamivir for treatment of influenza in infants less than one year: a retrospective analysis.
MedLine Citation:
PMID:  20035245     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Influenza causes proportionately more hospitalizations and deaths in infants in their first year of life than in older children. Oseltamivir is an effective treatment for childhood influenza, but few data are available in infants <1 year. METHODS: Medical records of infants <1 year admitted to hospital during the influenza seasons 2003-2007 were retrospectively analyzed to evaluate clinical presentation, and safety and outcome with oseltamivir therapy. Eligible infants were those with fever (>38 degrees C), influenza-like symptoms of sudden onset, positive rapid influenza test and parental consent, who received oseltamivir within 48 hours of the start of symptoms. Infants vaccinated against influenza or receiving immunosuppressants were excluded. RESULTS: In 157 evaluable infants (mean age 6.3 [SD 3.2] months; 86 boys), the most common presenting symptoms other than fever were rhinitis, pharyngitis, cough, feeding difficulties, and otitis media. During treatment, additional symptoms were observed in 78 (50%) infants; most of these were gastrointestinal (vomiting and diarrhea) and of mild intensity. Fever resolved in 128 (82%) infants within 36 hours of starting oseltamivir (136 [87%] within 48 hours). Complications were recorded in 84 patients (54%), the most serious of which were meningitis in 1 infant (1%), pneumonia in 9 (6%), and otitis media in 2 (1%). Twenty infants received antibiotics for secondary infections (10 [6%] before admission). CONCLUSIONS: The clinical presentation of influenza and outcome of oseltamivir treatment in infants <1 year was similar to that previously reported in older children, but mild gastrointestinal symptoms were common.
Kai Siedler; Heino Skopnik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  29     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-28     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  495-8     Citation Subset:  IM    
Klinikum Worms, Klinik für Kinder-und Jugendmedizin, Worms, Germany.
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MeSH Terms
Antiviral Agents / adverse effects,  therapeutic use*
Hospitals, Teaching
Influenza, Human / diagnosis,  drug therapy*
Oseltamivir / adverse effects,  therapeutic use*
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Antiviral Agents; 0/Oseltamivir
Comment In:
Rev Chilena Infectol. 2010 Apr;27(2):172-3   [PMID:  20564829 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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