Document Detail


Oseltamivir dosing in premature infants.
MedLine Citation:
PMID:  22807525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We conducted a 2-sample pharmacokinetic study of oseltamivir in 12 premature infants. Oseltamivir 1 mg/kg/dose twice daily in infants <38 weeks postmenstrual age (n=8) resulted in oseltamivir carboxylate exposure comparable to previously published pediatric data, which helps prospectively validate this regimen. Oseltamivir 3 mg/kg/dose once daily in premature infants >38 weeks postmenstrual age (born prematurely but chronologically past term, n=4) resulted in similar oseltamivir and oseltamivir carboxylate exposure. Although these results suggest persistence of immature renal function in this subgroup, further pharmacokinetic/pharmacodynamic description is required to confirm the appropriateness of this regimen.
Authors:
Christopher McPherson; Barbara Warner; David A Hunstad; Alexis Elward; Edward P Acosta
Related Documents :
10158455 - Falling diarrhoea mortality in northeastern brazil: did ort play a role?
1990255 - Infant leukemia in japan: clinical and biological analysis of 48 cases.
17154645 - Rotavirus vaccine rix4414 (rotarix).
7351295 - Intractable diarrhea of infancy due to intestinal coccidiosis.
10920165 - American academy of pediatrics. committee on nutrition. hypoallergenic infant formulas.
11328465 - A parent-completed developmental questionnaire: follow up of ex-premature infants.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-17
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  206     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-03     Completed Date:  2012-11-29     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  847-50     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Absorption
Antiviral Agents / administration & dosage,  blood,  pharmacokinetics*
Area Under Curve
Drug Administration Schedule
Humans
Infant, Newborn
Infant, Premature / metabolism*
Kidney / growth & development,  metabolism
Models, Biological
Oseltamivir / administration & dosage,  blood,  pharmacokinetics*
Prospective Studies
Grant Support
ID/Acronym/Agency:
N01 AI030025/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antiviral Agents; 20O93L6F9H/Oseltamivir
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lower Antibody Levels to Staphylococcus aureus Exotoxins are associated with Sepsis in Hospitalized ...
Next Document:  Fluid balance of elite female basketball players before and during game play.