| Oscillatory signaling processes: the how, the why and the where. | |
| | |
MedLine Citation:
|
PMID: 20971631 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Oscillatory processes in biological signal transduction have come under progressively increasing scrutiny in terms of their functional significance and mechanisms of emergence and regulation. Since oscillatory processes can be a by-product of rapid adaptation and can also easily emerge if the feedback underlying adaptive processes is inadvertently artificially enhanced, one needs to exercise caution in both claiming the existence of in vivo oscillations and seeking to assign to them a specific functional significance. Nevertheless, oscillations can be a powerful means of encoding and transferring information both in time and in space, thus possessing important potential advantages for evolutionary selection and stabilization. Thus periodicity in the cell responses to diverse persistent external stimuli might become a more recognized and even expected feature of signaling processes. |
| | |
Authors:
|
Raymond Cheong; Andre Levchenko |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Current opinion in genetics & development Volume: 20 ISSN: 1879-0380 ISO Abbreviation: Curr. Opin. Genet. Dev. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-16 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9111375 Medline TA: Curr Opin Genet Dev Country: England |
Other Details:
|
Languages: eng Pagination: 665-9 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010. Published by Elsevier Ltd. |
Affiliation:
|
Department of Biomedical Engineering, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological Animals Biological Clocks* Humans Signal Transduction* |
| Grant Support | |
ID/Acronym/Agency:
|
GM072024/GM/NIGMS NIH HHS; GM084332/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chemical biotechnology--a marriage of convenience and necessity.
Next Document: Phase III trial of irinotecan plus infusional 5-fluorouracil/folinic acid versus irinotecan plus oxa...