Document Detail

Oscillatory dynamics of the extracellular signal-regulated kinase pathway.
MedLine Citation:
PMID:  20810275     Owner:  NLM     Status:  MEDLINE    
The extracellular signal-regulated kinase (ERK) pathway is a central signaling pathway in development and disease and is regulated by multiple negative and positive feedback loops. Recent studies have shown negative feedback from ERK to upstream regulators can give rise to biochemical oscillations with a periodicity of between 15 and 30min. Feedback due to the stimulated transcription of negative regulators of the ERK pathway can also give rise to transcriptional oscillations with a periodicity of one to two hours. The biological significance of these oscillations is not clear, but recent evidence suggests that transcriptional oscillations participate in developmental processes, such as somite formation. Biochemical oscillations are more enigmatic, but could provide a mechanism for encoding different types of inputs into a common signaling pathway.
Harish Shankaran; H Steven Wiley
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  20     ISSN:  1879-0380     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-16     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  650-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, WA 99352, USA.
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MeSH Terms
Circadian Rhythm
Extracellular Signal-Regulated MAP Kinases / metabolism
MAP Kinase Signaling System*
Reg. No./Substance:
EC Signal-Regulated MAP Kinases

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